Proteasome Endopeptidase Complex

"Proteasome Endopeptidase Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Descriptor ID	D046988
MeSH Number(s)	D05.500.562.500 D08.811.277.656.918 D08.811.600.730
Concept/Terms	Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex Complex, Proteasome Endopeptidase Endopeptidase Complex, Proteasome Macropain Macroxyproteinase Multicatalytic Proteinase Proteinase, Multicatalytic Prosome Proteasome 20S Proteasome Proteasome, 20S Multicatalytic Endopeptidase Complex Complex, Multicatalytic Endopeptidase Endopeptidase Complex, Multicatalytic Ingensin Ingensin

Below are MeSH descriptors whose meaning is more general than "Proteasome Endopeptidase Complex".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Multienzyme Complexes [D05.500.562]
Proteasome Endopeptidase Complex [D05.500.562.500]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Proteasome Endopeptidase Complex [D08.811.277.656.918]
Multienzyme Complexes [D08.811.600]
Proteasome Endopeptidase Complex [D08.811.600.730]

Below are MeSH descriptors whose meaning is related to "Proteasome Endopeptidase Complex".

Below are MeSH descriptors whose meaning is more specific than "Proteasome Endopeptidase Complex".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proteasome Endopeptidase Complex" by people in this website by year, and whether "Proteasome Endopeptidase Complex" was a major or minor topic of these publications.

Bar chart showing 49 publications over 21 distinct years, with a maximum of 7 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	1	1
2005	1	2	3
2006	1	3	4
2007	1	1	2
2008	1	1	2
2009	0	3	3
2010	2	2	4
2011	0	1	1
2012	3	4	7
2013	1	0	1
2014	1	3	4
2015	1	1	2
2016	1	1	2
2017	2	1	3
2018	2	1	3
2019	1	1	2

Below are the most recent publications written about "Proteasome Endopeptidase Complex" by people in Profiles.

Awasthi V, Vilekar P, Rao G, Awasthi S. Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells. Immunobiology. 2020 03; 225(2):151886.

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More S, Zhu Z, Lin K, Huang C, Pushparaj S, Liang Y, Sathiaseelan R, Yang X, Liu L. Long non-coding RNA PSMB8-AS1 regulates influenza virus replication. RNA Biol. 2019 03; 16(3):340-353.

View in: PubMed
Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2018 11; 16(11):e2006145.

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Feng H, Li X, Chen H, Deng J, Zhang C, Liu J, Wang T, Zhang X, Dong J. GhHUB2, a ubiquitin ligase, is involved in cotton fiber development via the ubiquitin-26S proteasome pathway. J Exp Bot. 2018 10 12; 69(21):5059-5075.

View in: PubMed
Rao G, Houson H, Nkepang G, Yari H, Teng C, Awasthi V. Induction of gut proteasome activity in hemorrhagic shock and its recovery by treatment with diphenyldihaloketones CLEFMA and EF24. Am J Physiol Gastrointest Liver Physiol. 2018 08 01; 315(2):G318-G327.

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Blaber EA, Pecaut MJ, Jonscher KR. Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver. Int J Mol Sci. 2017 Sep 27; 18(10).

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Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24; 8(4):6742-6762.

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Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science. 2017 01 27; 355(6323):403-407.

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Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G180-91.

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Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio IIC, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. 2016 08 04; 19(2):205-216.

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