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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
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Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice.
Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1339-52.
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PubMed
subject areas
Aging
Aging
Animals
Animals
Blood-Brain Barrier
Blood-Brain Barrier
Brain
Brain
Cerebrovascular Circulation
Cerebrovascular Circulation
Cognition Disorders
Cognition Disorders
Diet, High-Fat
Diet, High-Fat
Disease Models, Animal
Disease Models, Animal
Hand Strength
Hand Strength
Hippocampus
Hippocampus
Male
Male
Maze Learning
Maze Learning
Mice
Mice
Mice, Inbred C57BL
Mice, Inbred C57BL
Microvessels
Microvessels
Neovascularization, Physiologic
Neovascularization, Physiologic
Obesity
Obesity
Oxidative Stress
Oxidative Stress
Pericytes
Pericytes
Transcriptome
Transcriptome
authors with profiles
Anna Csiszar
Stefano Tarantini
William Edmund Sonntag
Jonathan D. Wren
Zoltan Ungvari