Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.
Linette GP, Becker-Hapak M, Skidmore ZL, Baroja ML, Xu C, Hundal J, Spencer DH, Fu W, Cummins C, Robnett M, Kaabinejadian S, Hildebrand WH, Magrini V, Demeter R, Krupnick AS, Griffith OL, Griffith M, Mardis ER, Carreno BM. Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23662-23670.
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Amino Acid Substitution
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Amino Acid Substitution
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Antigens, Neoplasm
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Antigens, Neoplasm
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Cancer Vaccines
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Cancer Vaccines
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CD8-Positive T-Lymphocytes
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CD8-Positive T-Lymphocytes
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Clone Cells
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Clone Cells
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Dendritic Cells
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Dendritic Cells
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DNA, Neoplasm
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DNA, Neoplasm
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HLA Antigens
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HLA Antigens
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Humans
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Humans
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Lung Neoplasms
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Lung Neoplasms
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Lymphocytes, Tumor-Infiltrating
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Lymphocytes, Tumor-Infiltrating
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Melanoma
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Melanoma
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Polymorphism, Single Nucleotide
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Polymorphism, Single Nucleotide
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Receptors, Antigen, T-Cell, alpha-beta
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Receptors, Antigen, T-Cell, alpha-beta
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Retroperitoneal Neoplasms
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Retroperitoneal Neoplasms
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Sequence Analysis, DNA
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Sequence Analysis, DNA
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T-Cell Antigen Receptor Specificity
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T-Cell Antigen Receptor Specificity
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T-Lymphocyte Subsets
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T-Lymphocyte Subsets
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Tumor Escape
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Tumor Escape
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Vaccination
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Vaccination