Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
| Descriptor ID |
D000072183
|
| MeSH Number(s) |
D08.811.277.352.650.624.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases".
This graph shows the total number of publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in this website by year, and whether "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 4 | 4 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases" by people in Profiles.
-
TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1. Sci Signal. 2010 May 18; 3(122):ra38.
-
Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol. 2005 May; 25(10):4211-20.
-
Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. J Immunol. 2004 Oct 15; 173(8):5036-45.
-
Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow. J Exp Med. 2004 Jan 19; 199(2):243-54.
-
Negative signaling. Mol Immunol. 2002 Dec; 39(9):519-20.
-
How do inhibitory phosphatases work? Mol Immunol. 2002 Dec; 39(9):521-9.
-
The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-mediated phagocytosis through immunoreceptor tyrosine-based activation motif-bearing phagocytic receptors. Blood. 2002 Nov 01; 100(9):3374-82.
-
Regulation of signal transduction by the Fc gamma receptor family members and their involvement in autoimmunity. Curr Dir Autoimmun. 2002; 5:1-29.
-
Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase. J Biol Chem. 2000 Sep 22; 275(38):29275-82.
-
The SH2-containing 5'-inositol phosphatase (SHIP) is tyrosine phosphorylated after Fc gamma receptor clustering in monocytes. J Immunol. 1999 Jun 01; 162(11):6458-65.