Interferon-Induced Helicase, IFIH1
"Interferon-Induced Helicase, IFIH1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
| Descriptor ID |
D000072640
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| MeSH Number(s) |
D08.811.913.696.445.735.720.249.875
|
| Concept/Terms |
Interferon-Induced Helicase, IFIH1- Interferon-Induced Helicase, IFIH1
- Helicase, IFIH1 Interferon-Induced
- IFIH1 Interferon-Induced Helicase
- Interferon Induced Helicase, IFIH1
- Helicard
- Melanoma Differentiation-Associated Protein 5
- Melanoma Differentiation Associated Protein 5
- CADM-140 Autoantigen
- Autoantigen, CADM-140
- CADM 140 Autoantigen
- Interferon Induced with Helicase C Domain 1
- Interferon-Induced Helicase C Domain-Containing Protein 1
- Interferon Induced Helicase C Domain Containing Protein 1
- IFIH1 Protein
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Below are MeSH descriptors whose meaning is more general than "Interferon-Induced Helicase, IFIH1".
Below are MeSH descriptors whose meaning is more specific than "Interferon-Induced Helicase, IFIH1".
This graph shows the total number of publications written about "Interferon-Induced Helicase, IFIH1" by people in this website by year, and whether "Interferon-Induced Helicase, IFIH1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interferon-Induced Helicase, IFIH1" by people in Profiles.
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Mamyrova G, Kishi T, Shi M, Targoff IN, Huber AM, Curiel RV, Miller FW, Rider LG. Anti-MDA5 autoantibodies associated with juvenile dermatomyositis constitute a distinct phenotype in North America. Rheumatology (Oxford). 2021 04 06; 60(4):1839-1849.
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Mamyrova G, Kishi T, Targoff IN, Ehrlich A, Curiel RV, Rider LG. Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis. Rheumatology (Oxford). 2018 11 01; 57(11):1956-1963.
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Hoa S, Troyanov Y, Fritzler MJ, Targoff IN, Chartrand S, Mansour AM, Rich E, Boudabbouz H, Bourré-Tessier J, Albert M, Goulet JR, Landry M, Senécal JL. Describing and expanding the clinical phenotype of anti-MDA5-associated rapidly progressive interstitial lung disease: case series of nine Canadian patients and literature review. Scand J Rheumatol. 2018 05; 47(3):210-224.
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Munroe ME, Pezant N, Brown MA, Fife DA, Guthridge JM, Kelly JA, Wiley G, Gaffney PM, James JA, Montgomery CG. Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis. PLoS One. 2017; 12(2):e0171193.
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Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcón GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcón-Riquelme ME, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013; 9(2):e1003222.