"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
- Bestrophin Proteins
- Bestrophin Family
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
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Below are the most recent publications written about "Bestrophins" by people in Profiles.
S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA. Hum Mol Genet. 2013 Apr 15; 22(8):1632-42.
Unexpected transcriptional activity of the human VMD2 promoter in retinal development. Adv Exp Med Biol. 2010; 664:211-6.
Expression of Cre recombinase in retinal Müller cells. Vision Res. 2009 Mar; 49(6):615-21.
Inducible expression of cre recombinase in the retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1248-53.