"Allosteric Site" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
| Descriptor ID |
D000495
|
| MeSH Number(s) |
G02.111.570.120.147
|
| Concept/Terms |
Allosteric Site- Allosteric Site
- Allosteric Sites
- Site, Allosteric
- Sites, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Site".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Site".
This graph shows the total number of publications written about "Allosteric Site" by people in this website by year, and whether "Allosteric Site" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Allosteric Site" by people in Profiles.
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Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol. 2022 May 01; 78(Pt 5):571-585.
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Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling. Biophys J. 2019 03 05; 116(5):818-830.
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Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy. Sci Rep. 2016 08 02; 6:30832.
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Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem. 2010 Jun 04; 285(23):17614-27.
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Role of PDI in regulating tissue factor: FVIIa activity. Thromb Res. 2010 Apr; 125 Suppl 1:S38-41.
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Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites. Biochemistry. 2003 Aug 19; 42(32):9712-21.
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Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase. Biochemistry. 2001 Jun 26; 40(25):7446-52.
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Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound. J Mol Biol. 2000 Oct 20; 303(2):279-86.
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Kinetic mechanism of Ascaris suum phosphofructokinase desensitized to allosteric modulation by diethylpyrocarbonate modification. J Biol Chem. 1987 Oct 15; 262(29):14074-9.
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Reaction of Ascaris suum phosphofructokinase with diethylpyrocarbonate. Inactivation and desensitization to allosteric modulation. J Biol Chem. 1987 Oct 15; 262(29):14068-73.