Cytochrome P-450 Enzyme System
"Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
|Cytochrome P-450 Enzyme System
- Cytochrome P-450 Enzyme System
- Cytochrome P 450 Enzyme System
- Cytochrome P450
- P-450 Enzymes
- Enzymes, P-450
- P 450 Enzymes
- P450 Enzymes
- Enzymes, P450
- CYP450 Family
- Cytochrome P450 Superfamily
- Superfamily, Cytochrome P450
- Cytochrome P-450 Superfamily
- Cytochrome P 450 Superfamily
- Superfamily, Cytochrome P-450
- Cytochrome p450 Families
- Cytochrome P-450 Families
- Cytochrome P 450 Families
- CYP450 Superfamily
- Superfamily, CYP450
- Cytochrome P-450
- Cytochrome P 450
- Cytochrome P-450 Enzymes
- Cytochrome P 450 Enzymes
- Enzymes, Cytochrome P-450
- P-450 Enzymes, Cytochrome
Cytochrome P-450 Monooxygenase
- Cytochrome P-450 Monooxygenase
- Cytochrome P 450 Monooxygenase
- Monooxygenase, Cytochrome P-450
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Monooxygenase, Cytochrome P-450-Dependent
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme System".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme System".
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Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles.
Roughened graphite biointerfaced with P450 liver microsomes: Surface and electrochemical characterizations. Colloids Surf B Biointerfaces. 2020 May; 189:110790.
An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s. Sci Rep. 2019 12 02; 9(1):18023.
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group. ACS Chem Biol. 2019 06 21; 14(6):1305-1309.
Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins. Metabolomics. 2019 05 29; 15(6):85.
Effects of N-carbamylglutamate and L-arginine on steroidogenesis and gene expression in bovine granulosa cells. Anim Reprod Sci. 2018 Jan; 188:85-92.
A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of a,ß-Epoxyketone Proteasome Inhibitors. J Am Chem Soc. 2016 Apr 06; 138(13):4342-5.
Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. J Cereb Blood Flow Metab. 2015 Nov; 35(11):1871-81.
Electrocatalysis by subcellular liver fractions bound to carbon nanostructures for stereoselective green drug metabolite synthesis. Chem Commun (Camb). 2015 Jul 25; 51(58):11681-4.
A simple construction of electrochemical liver microsomal bioreactor for rapid drug metabolism and inhibition assays. Anal Chem. 2015; 87(9):4712-8.
A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition. Tumour Biol. 2014 Sep; 35(9):8597-606.