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Kamiya Mehla

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDepartment of Oncology Science
AddressBMSB 1053
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, Santana JF, Miklavcic WR, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. Elife. 2024 Jul 08; 12. PMID: 38973593; PMCID: PMC11230627.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 May; 26(5):840. PMID: 38641662; PMCID: PMC11098729.
      Citations:    Fields:    
    3. Murthy D, Attri KS, Suresh V, Rajacharya GH, Valenzuela CA, Thakur R, Zhao J, Shukla SK, Chaika NV, LaBreck D, Rao CV, Hollingsworth MA, Mehla K, Singh PK. The MUC1-HIF-1a signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling. Proc Natl Acad Sci U S A. 2024 Apr 02; 121(14):e2315509121. PMID: 38547055; PMCID: PMC10998584.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 Mar 01. PMID: 38429478.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Fujii Y, Mehla K. Measurement of Metabolic Alteration in Immune Cells Under Hypoxia. Methods Mol Biol. 2024; 2755:201-212. PMID: 38319580.
      Citations:    Fields:    Translation:AnimalsCells
    6. He C, Wang D, Shukla SK, Hu T, Thakur R, Fu X, King RJ, Kollala SS, Attri KS, Murthy D, Chaika NV, Fujii Y, Gonzalez D, Pacheco CG, Qiu Y, Singh PK, Locasale JW, Mehla K. Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells. Cancer Discov. 2023 Nov 07. PMID: 37931287.
      Citations: 4     Fields:    Translation:HumansCells
    7. Singh PK, Mehla K. LXR Signaling-Mediated Cholesterol Metabolism Reprogramming Regulates Cancer Cell Metastasis. Cancer Res. 2023 06 02; 83(11):1759-1761. PMID: 37264829; PMCID: PMC10334847.
      Citations: 1     Fields:    Translation:Humans
    8. Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. bioRxiv. 2023 Apr 05. PMID: 37066260; PMCID: PMC10103971.
      Citations:    
    9. King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 02; 41(7):971-982. PMID: 35001076; PMCID: PMC8840971.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    10. King RJ, Singh PK, Mehla K. The cholesterol pathway: impact on immunity and cancer. Trends Immunol. 2022 01; 43(1):78-92. PMID: 34942082; PMCID: PMC8812650.
      Citations: 42     Fields:    Translation:HumansAnimals
    11. Mehla K, Hollingsworth MA. Inflammatory and immune effects on tumor progression. Trends Immunol. 2022 02; 43(2):93-95. PMID: 34953686.
      Citations:    Fields:    Translation:Humans
    12. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, Singh PK, Madiyalakan R, Daniels-Wells TR, Penichet ML, Nicodemus CF, Poole JA, Jaffee EM, Hollingsworth MA, Mehla K. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021 12; 20(12):2457-2468. PMID: 34625505; PMCID: PMC8762606.
      Citations: 1     Fields:    Translation:HumansAnimals
    13. Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 11; 161(5):1584-1600. PMID: 34245764; PMCID: PMC8546779.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    14. Ahmad IM, Dafferner AJ, O'Connell KA, Mehla K, Britigan BE, Hollingsworth MA, Abdalla MY. Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2021 May 08; 13(9). PMID: 34066839; PMCID: PMC8125955.
      Citations: 8     
    15. Markov SD, Gonzalez D, Mehla K. Preclinical Models for Studying the Impact of Macrophages on Cancer Cachexia. Curr Protoc Pharmacol. 2020 12; 91(1):e80. PMID: 33264501; PMCID: PMC8099022.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 07 06; 217(7). PMID: 32441762; PMCID: PMC7336299.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    17. Mundry CS, Eberle KC, Singh PK, Hollingsworth MA, Mehla K. Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal. Biochim Biophys Acta Rev Cancer. 2020 08; 1874(1):188387. PMID: 32579889; PMCID: PMC7483650.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    18. Shukla SK, Markov SD, Attri KS, Vernucci E, King RJ, Dasgupta A, Grandgenett PM, Hollingsworth MA, Singh PK, Yu F, Mehla K. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Lett. 2020 08 01; 484:29-39. PMID: 32344015; PMCID: PMC7286478.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    19. Mehla K, Singh PK. Metabolic Regulation of Macrophage Polarization in Cancer. Trends Cancer. 2019 12; 5(12):822-834. PMID: 31813459; PMCID: PMC7187927.
      Citations: 205     Fields:    Translation:HumansCells
    20. Mehla K, Singh PK. Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer. Clin Cancer Res. 2020 01 01; 26(1):6-8. PMID: 31628144; PMCID: PMC6942627.
      Citations: 17     Fields:    Translation:HumansCells
    21. Haney SL, Varney ML, Chhonker YS, Shin S, Mehla K, Crawford AJ, Smith HJ, Smith LM, Murry DJ, Hollingsworth MA, Holstein SA. Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma. Oncogene. 2019 06; 38(26):5308-5320. PMID: 30918331; PMCID: PMC6597278.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    22. Soni KS, Thomas D, Caffrey T, Mehla K, Lei F, O'Connell KA, Sagar S, Lele SM, Hollingsworth MA, Radhakrishnan P, Bronich TK. A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer. J Pharmacol Exp Ther. 2019 09; 370(3):894-901. PMID: 30683666; PMCID: PMC6807295.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Attri KS, Mehla K, Shukla SK, Singh PK. Microscale Gene Expression Analysis of Tumor-Associated Macrophages. Sci Rep. 2018 02 05; 8(1):2408. PMID: 29402936; PMCID: PMC5799305.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Attri KS, Mehla K, Singh PK. Evaluation of Macrophage Polarization in Pancreatic Cancer Microenvironment Under Hypoxia. Methods Mol Biol. 2018; 1742:265-276. PMID: 29330807.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Mehla K, Tremayne J, Grunkemeyer JA, O'Connell KA, Steele MM, Caffrey TC, Zhu X, Yu F, Singh PK, Schultes BC, Madiyalakan R, Nicodemus CF, Hollingsworth MA. Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors. Cancer Immunol Immunother. 2018 Mar; 67(3):445-457. PMID: 29204701; PMCID: PMC7108804.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 09 11; 32(3):392. PMID: 28898700.
      Citations: 37     Fields:    
    27. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 07 10; 32(1):71-87.e7. PMID: 28697344; PMCID: PMC5533091.
      Citations: 221     Fields:    Translation:HumansCells
    28. Shukla SK, Dasgupta A, Mehla K, Gunda V, Vernucci E, Souchek J, Goode G, King R, Mishra A, Rai I, Nagarajan S, Chaika NV, Yu F, Singh PK. Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth. Oncotarget. 2015 Dec 01; 6(38):41146-61. PMID: 26510913; PMCID: PMC4747396.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    29. Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2014; 2:18. PMID: 25228990; PMCID: PMC4165433.
      Citations: 142     
    30. Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014 Mar 04; 53(8):1360-72. PMID: 24512202; PMCID: PMC3985919.
      Citations: 31     Fields:    Translation:HumansCells
    31. Mehla K, Singh PK. MUC1: a novel metabolic master regulator. Biochim Biophys Acta. 2014 Apr; 1845(2):126-35. PMID: 24418575; PMCID: PMC4045475.
      Citations: 52     Fields:    Translation:HumansCells
    32. Mehla K, Balwani S, Agrawal A, Ghosh B. Ethyl gallate attenuates acute lung injury through Nrf2 signaling. Biochimie. 2013 Dec; 95(12):2404-14. PMID: 24018486.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    33. Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK. MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13787-92. PMID: 22869720; PMCID: PMC3427054.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    34. Singh PK, Brand RE, Mehla K. MicroRNAs in pancreatic cancer metabolism. Nat Rev Gastroenterol Hepatol. 2012 Apr 17; 9(6):334-44. PMID: 22508159; PMCID: PMC4045488.
      Citations: 28     Fields:    Translation:Humans
    35. Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR, Hollingsworth MA, Singh PK. Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One. 2012; 7(3):e32996. PMID: 22412968; PMCID: PMC3296773.
      Citations: 59     Fields:    Translation:HumansCells
    36. Singh D, Singh PK, Chaudhary S, Mehla K, Kumar S. Exome sequencing and advances in crop improvement. Adv Genet. 2012; 79:87-121. PMID: 22989766.
      Citations: 6     Fields:    Translation:Animals
    37. Mehla K, Balwani S, Kulshreshtha A, Nandi D, Jaisankar P, Ghosh B. Ethyl gallate isolated from Pistacia integerrima Linn. inhibits cell adhesion molecules by blocking AP-1 transcription factor. J Ethnopharmacol. 2011 Oct 11; 137(3):1345-52. PMID: 21843619.
      Citations: 10     Fields:    Translation:AnimalsCells
    38. Singh PK, Mehla K, Hollingsworth MA, Johnson KR. Regulation of Aerobic Glycolysis by microRNAs in Cancer. Mol Cell Pharmacol. 2011; 3(3):125-134. PMID: 22792411; PMCID: PMC3392682.
      Citations: 35     
    39. Sharma M, Mehla K, Batra J, Ghosh B. Association of a chromosome 1q21 locus in close proximity to a late cornified envelope-like proline-rich 1 (LELP1) gene with total serum IgE levels. J Hum Genet. 2007; 52(4):378-383. PMID: 17387579.
      Citations: 7     Fields:    Translation:HumansCells
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