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Surendra Kumar Shukla

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDepartment of Oncology Science
AddressBMSB 332
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, Santana JF, Miklavcic WR, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. Elife. 2024 Jul 08; 12. PMID: 38973593; PMCID: PMC11230627.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Sharma H, Mondal S, Urquiza U, Esparza C, Bartlett S, Santa-Pinter L, Hill H, White M, Sharma P, Luckett-Chastain L, Cooper A, Rasel M, Gao P, Battaile KP, Shukla SK, Lovell S, Ihnat MA. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur J Med Chem. 2024 Sep 05; 275:116598. PMID: 38925013.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 May; 26(5):840. PMID: 38641662; PMCID: PMC11098729.
      Citations:    Fields:    
    4. Murthy D, Attri KS, Suresh V, Rajacharya GH, Valenzuela CA, Thakur R, Zhao J, Shukla SK, Chaika NV, LaBreck D, Rao CV, Hollingsworth MA, Mehla K, Singh PK. The MUC1-HIF-1a signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling. Proc Natl Acad Sci U S A. 2024 Apr 02; 121(14):e2315509121. PMID: 38547055; PMCID: PMC10998584.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 Mar 01. PMID: 38429478.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Verma C, Pawar VA, Srivastava S, Tyagi A, Kaushik G, Shukla SK, Kumar V. Cancer Vaccines in the Immunotherapy Era: Promise and Potential. Vaccines (Basel). 2023 Nov 29; 11(12). PMID: 38140187; PMCID: PMC10747700.
      Citations: 3     
    7. He C, Wang D, Shukla SK, Hu T, Thakur R, Fu X, King RJ, Kollala SS, Attri KS, Murthy D, Chaika NV, Fujii Y, Gonzalez D, Pacheco CG, Qiu Y, Singh PK, Locasale JW, Mehla K. Vitamin B6 competition in the tumor microenvironment hampers antitumor functions of NK cells. Cancer Discov. 2023 Nov 07. PMID: 37931287.
      Citations: 4     Fields:    Translation:HumansCells
    8. Jaiswara PK, Shukla SK. Chemotherapy-Mediated Neuronal Aberration. Pharmaceuticals (Basel). 2023 Aug 16; 16(8). PMID: 37631080; PMCID: PMC10459787.
      Citations: 1     
    9. Pawar VA, Srivastava S, Tyagi A, Tayal R, Shukla SK, Kumar V. Efficacy of Bioactive Compounds in the Regulation of Metabolism and Pathophysiology in Cardiovascular Diseases. Curr Cardiol Rep. 2023 Jul 17. PMID: 37458865.
      Citations: 2     Fields:    Translation:HumansCells
    10. Kumar V, Shukla SK. Editorial: Identification and characterization of molecular targets in hepatocellular carcinoma. Front Mol Biosci. 2023; 10:1202614. PMID: 37435190; PMCID: PMC10331817.
      Citations: 1     
    11. Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N, LaBreck DA, Mallareddy JR, Price DH, Natarajan A, Mehla K, Sykes DB, Hollingsworth MA, Singh PK. DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. bioRxiv. 2023 Apr 05. PMID: 37066260; PMCID: PMC10103971.
      Citations:    
    12. Mullen NJ, Thakur R, Shukla SK, Chaika NV, Kollala SS, Wang D, He C, Fujii Y, Sharma S, Mulder SE, Sykes DB, Singh PK. ENT1 blockade by CNX-774 overcomes resistance to DHODH inhibition in pancreatic cancer. Cancer Lett. 2023 01 01; 552:215981. PMID: 36341997.
      Citations: 4     Fields:    Translation:Animals
    13. Mohapatra BC, Mirza S, Bele A, Gurumurthy CB, Raza M, Saleem I, Storck MD, Sarkar A, Kollala SS, Shukla SK, Southekal S, Wagner KU, Qiu F, Lele SM, Alsaleem MA, Rakha EA, Guda C, Singh PK, Cardiff RD, Band H, Band V. Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism. Mol Cancer Res. 2022 09 02; 20(9):1391-1404. PMID: 35675041; PMCID: PMC9437571.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Kamal M, Pratap AR, Naved M, Zamani AS, Nancy P, Ritonga M, Shukla SK, Sammy F. Machine Learning and Image Processing Enabled Evolutionary Framework for Brain MRI Analysis for Alzheimer's Disease Detection. Comput Intell Neurosci. 2022; 2022:5261942. PMID: 35419043; PMCID: PMC8995544.
      Citations: 2     Fields:    Translation:Humans
    15. Xu PC, You M, Yu SY, Luan Y, Eldani M, Caffrey TC, Grandgenett PM, O'Connell KA, Shukla SK, Kattamuri C, Hollingsworth MA, Singh PK, Thompson TB, Chung S, Kim SY. Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling. Sci Rep. 2022 01 31; 12(1):1659. PMID: 35102236; PMCID: PMC8803848.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 02; 41(7):971-982. PMID: 35001076; PMCID: PMC8840971.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    17. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, Singh PK, Madiyalakan R, Daniels-Wells TR, Penichet ML, Nicodemus CF, Poole JA, Jaffee EM, Hollingsworth MA, Mehla K. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021 12; 20(12):2457-2468. PMID: 34625505; PMCID: PMC8762606.
      Citations: 1     Fields:    Translation:HumansAnimals
    18. Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 11; 161(5):1584-1600. PMID: 34245764; PMCID: PMC8546779.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    19. Soliman GA, Shukla SK, Etekpo A, Gunda V, Steenson SM, Gautam N, Alnouti Y, Singh PK. The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor Growth. Curr Dev Nutr. 2020 Sep; 4(9):nzaa131. PMID: 32908958; PMCID: PMC7467276.
      Citations: 3     
    20. Mulder SE, Dasgupta A, King RJ, Abrego J, Attri KS, Murthy D, Shukla SK, Singh PK. JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia. Cancer Lett. 2020 10 28; 491:70-77. PMID: 32735910; PMCID: PMC7541723.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    21. Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 07 06; 217(7). PMID: 32441762; PMCID: PMC7336299.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    22. Shukla SK, Markov SD, Attri KS, Vernucci E, King RJ, Dasgupta A, Grandgenett PM, Hollingsworth MA, Singh PK, Yu F, Mehla K. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Lett. 2020 08 01; 484:29-39. PMID: 32344015; PMCID: PMC7286478.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    23. Vernucci E, Abrego J, Gunda V, Shukla SK, Dasgupta A, Rai V, Chaika N, Buettner K, Illies A, Yu F, Lazenby AJ, Swanson BJ, Singh PK. Metabolic Alterations in Pancreatic Cancer Progression. Cancers (Basel). 2019 Dec 18; 12(1). PMID: 31861288; PMCID: PMC7016676.
      Citations: 20     
    24. Laschanzky RS, Humphrey LE, Ma J, Smith LM, Enke TJ, Shukla SK, Dasgupta A, Singh PK, Howell GM, Brattain MG, Ly QP, Black AR, Black JD. Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy. Cancers (Basel). 2019 Sep 07; 11(9). PMID: 31500290; PMCID: PMC6770665.
      Citations: 12     
    25. Shukla SK, Dasgupta A, Mulder SE, Singh PK. Molecular and Physiological Evaluation of Pancreatic Cancer-Induced Cachexia. Methods Mol Biol. 2019; 1882:321-333. PMID: 30378066; PMCID: PMC6709446.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Dasgupta A, Shukla SK, Gunda V, King RJ, Singh PK. Evaluating the Metabolic Alterations in Pancreatic Cancer. Methods Mol Biol. 2019; 1882:221-228. PMID: 30378058.
      Citations: 2     Fields:    Translation:HumansCells
    27. Attri KS, Mehla K, Shukla SK, Singh PK. Microscale Gene Expression Analysis of Tumor-Associated Macrophages. Sci Rep. 2018 02 05; 8(1):2408. PMID: 29402936; PMCID: PMC5799305.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Shukla SK, King RJ, Singh PK. Transcriptional Profiling Using RNA-Seq to Study Hypoxia-Mediated Gene Regulation. Methods Mol Biol. 2018; 1742:55-66. PMID: 29330790.
      Citations: 2     Fields:    Translation:Humans
    29. Shukla SK, Mulder SE, Singh PK. Hypoxia-Mediated In Vivo Tumor Glucose Uptake Measurement and Analysis. Methods Mol Biol. 2018; 1742:107-113. PMID: 29330794.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 09 11; 32(3):392. PMID: 28898700.
      Citations: 37     Fields:    
    31. Gebregiworgis T, Purohit V, Shukla SK, Tadros S, Chaika NV, Abrego J, Mulder SE, Gunda V, Singh PK, Powers R. Glucose Limitation Alters Glutamine Metabolism in MUC1-Overexpressing Pancreatic Cancer Cells. J Proteome Res. 2017 10 06; 16(10):3536-3546. PMID: 28809118; PMCID: PMC5634392.
      Citations: 22     Fields:    Translation:HumansCells
    32. Tadros S, Shukla SK, King RJ, Gunda V, Vernucci E, Abrego J, Chaika NV, Yu F, Lazenby AJ, Berim L, Grem J, Sasson AR, Singh PK. De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. Cancer Res. 2017 10 15; 77(20):5503-5517. PMID: 28811332; PMCID: PMC5645242.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    33. Gunda V, Souchek J, Abrego J, Shukla SK, Goode GD, Vernucci E, Dasgupta A, Chaika NV, King RJ, Li S, Wang S, Yu F, Bessho T, Lin C, Singh PK. MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer. Clin Cancer Res. 2017 Oct 01; 23(19):5881-5891. PMID: 28720669; PMCID: PMC5626603.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    34. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 07 10; 32(1):71-87.e7. PMID: 28697344; PMCID: PMC5533091.
      Citations: 221     Fields:    Translation:HumansCells
    35. Abrego J, Gunda V, Vernucci E, Shukla SK, King RJ, Dasgupta A, Goode G, Murthy D, Yu F, Singh PK. GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. Cancer Lett. 2017 08 01; 400:37-46. PMID: 28455244; PMCID: PMC5488721.
      Citations: 51     Fields:    Translation:HumansCells
    36. Mondal G, Kumar V, Shukla SK, Singh PK, Mahato RI. EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer. Biomacromolecules. 2016 Jan 11; 17(1):301-13. PMID: 26626700; PMCID: PMC4829353.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    37. Shukla SK, Dasgupta A, Mehla K, Gunda V, Vernucci E, Souchek J, Goode G, King R, Mishra A, Rai I, Nagarajan S, Chaika NV, Yu F, Singh PK. Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth. Oncotarget. 2015 Dec 01; 6(38):41146-61. PMID: 26510913; PMCID: PMC4747396.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    38. Yang S, Zhang L, Purohit V, Shukla SK, Chen X, Yu F, Fu K, Chen Y, Solheim J, Singh PK, Song W, Dong J. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Oncotarget. 2015 Nov 03; 6(34):36019-31. PMID: 26440309; PMCID: PMC4742158.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    39. Shukla SK, Gunda V, Abrego J, Haridas D, Mishra A, Souchek J, Chaika NV, Yu F, Sasson AR, Lazenby AJ, Batra SK, Singh PK. MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism. Oncotarget. 2015 Aug 07; 6(22):19118-31. PMID: 26046375; PMCID: PMC4662479.
      Citations: 36     Fields:    Translation:HumansCells
    40. Peddada KV, Peddada KV, Shukla SK, Mishra A, Verma V. Role of Curcumin in Common Musculoskeletal Disorders: a Review of Current Laboratory, Translational, and Clinical Data. Orthop Surg. 2015 Aug; 7(3):222-31. PMID: 26311096; PMCID: PMC6583735.
      Citations: 24     Fields:    Translation:Humans
    41. Rajput P, Shukla SK, Kumar V. The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF. Virol J. 2015 Apr 14; 12:62. PMID: 25890091; PMCID: PMC4424551.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    42. Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2014; 2:18. PMID: 25228990; PMCID: PMC4165433.
      Citations: 142     
    43. Kapoor NR, Ahuja R, Shukla SK, Kumar V. The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression. FEBS Lett. 2013 May 02; 587(9):1287-92. PMID: 23507139.
      Citations: 10     Fields:    Translation:HumansCells
    44. Shukla SK, Kumar V. Hepatitis B virus X protein and c-Myc cooperate in the upregulation of ribosome biogenesis and in cellular transformation. FEBS J. 2012 Oct; 279(20):3859-71. PMID: 22889122.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    45. Jayani RS, Shukla SK, Gupta R. Screening of Bacterial Strains for Polygalacturonase Activity: Its Production by Bacillus sphaericus (MTCC 7542). Enzyme Res. 2010 Oct 31; 2010:306785. PMID: 21052535; PMCID: PMC2968121.
      Citations: 11     
    46. Choedon T, Shukla SK, Kumar V. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. J Ethnopharmacol. 2010 May 27; 129(2):208-13. PMID: 20307637.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    47. Saxena S, Shukla S, Thakur A, Gupta R. Immobilization of polygalacturonase from Aspergillus niger onto activated polyethylene and its application in apple juice clarification. Acta Microbiol Immunol Hung. 2008 Mar; 55(1):33-51. PMID: 18507150.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    48. Shukla SK, McCarthy D. An activity gel assay for the detection of DNA helicases and nucleases from cell-free extracts. Nucleic Acids Res. 1994 May 11; 22(9):1626-31. PMID: 8202362; PMCID: PMC308039.
      Citations:    Fields:    Translation:Cells
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