"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 2 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Discriminating cocaine use from other sympathomimetics using wearable electrocardiographic (ECG) sensors. Drug Alcohol Depend. 2023 09 01; 250:110898.
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Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addict Biol. 2022 03; 27(2):e13120.
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Reversible Fulminant Hepatitis Secondary to Cocaine in the Setting of ?-Blocker Use. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620924203.
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Cocaine and chronic stress exposure produce an additive increase in neuronal activity in the basolateral amygdala. Addict Biol. 2021 Jan; 26(1):e12848.
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?eta-blocker therapy in cocaine-associated heart failure: Attempting to mitigate the risk. Int J Cardiol. 2019 05 15; 283:135.
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A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Addict Biol. 2020 07; 25(4):e12763.
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A Computational Modeling Approach Supports Negative Reinforcement Theories of Addiction. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 03; 4(3):218-219.
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Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo. ACS Chem Neurosci. 2018 03 21; 9(3):514-521.
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Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. Neuropsychopharmacology. 2017 02; 42(3):707-715.
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IMAGES IN CLINICAL MEDICINE. Cocaine-Induced Coronary-Artery Vasospasm. N Engl J Med. 2016 Feb 04; 374(5):e5.