"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addict Biol. 2022 03; 27(2):e13120.
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?eta-blocker therapy in cocaine-associated heart failure: Attempting to mitigate the risk. Int J Cardiol. 2019 05 15; 283:135.
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A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Addict Biol. 2020 07; 25(4):e12763.
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A Computational Modeling Approach Supports Negative Reinforcement Theories of Addiction. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 03; 4(3):218-219.
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Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. Neuropsychopharmacology. 2017 02; 42(3):707-715.
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IMAGES IN CLINICAL MEDICINE. Cocaine-Induced Coronary-Artery Vasospasm. N Engl J Med. 2016 Feb 04; 374(5):e5.
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Severity and interference of chronic pain in methadone-maintained outpatients. Pain Med. 2014 Sep; 15(9):1540-8.
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A voxel-based morphometry study of young occasional users of amphetamine-type stimulants and cocaine. Drug Alcohol Depend. 2014 Feb 01; 135:104-11.
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Cocaine-induced postpartum coronary artery dissection: a case report and 80-year review of literature. J Invasive Cardiol. 2013 Aug; 25(8):E163-6.
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Elevated troponin levels in previously healthy children: value of diagnostic modalities and the importance of a drug screen. Cardiol Young. 2014 Apr; 24(2):283-9.