Enzyme Inhibitors

"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Descriptor ID	D004791
MeSH Number(s)	D27.505.519.389
Concept/Terms	Enzyme Inhibitors Enzyme Inhibitors Inhibitors, Enzyme

Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]

Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.

Bar chart showing 197 publications over 27 distinct years, with a maximum of 17 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	0	3
1996	0	5	5
1997	2	6	8
1998	1	3	4
1999	5	4	9
2000	1	5	6
2001	2	12	14
2002	5	12	17
2003	2	8	10
2004	2	9	11
2005	3	3	6
2006	3	5	8
2007	3	9	12
2008	2	10	12
2009	7	2	9
2010	2	7	9
2011	2	5	7
2012	3	2	5
2013	4	6	10
2014	1	3	4
2015	3	5	8
2016	4	1	5
2017	2	2	4
2018	2	0	2
2019	4	2	6
2020	1	1	2
2021	1	0	1

Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.

Karsten W, Thomas LM, Fleming C, Seabourn P, Bruxvoort C, Chooback L. Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid. Arch Biochem Biophys. 2021 05 15; 702:108819.

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Muddala NP, White JC, Nammalwar B, Pratt I, Thomas LM, Bunce RA, Berlin KD, Bourne CR. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.

View in: PubMed
Buonpane C, Yuan C, Wood D, Ares G, Klonoski SC, Hunter CJ. ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2020 04 01; 318(4):G781-G792.

View in: PubMed
Csiszar A, Yabluchanskiy A, Ungvari A, Ungvari Z, Tarantini S. Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice. Geroscience. 2019 10; 41(5):609-617.

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Hendricson A, Umlauf S, Choi JY, Thekkiniath J, Surovtseva YV, Fuller KK, Reynolds TB, Voelker DR, Ben Mamoun C. High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay. J Biol Chem. 2019 08 09; 294(32):12146-12156.

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Liu T, Zhang M, Mukosera GT, Borchardt D, Li Q, Tipple TE, Ishtiaq Ahmed AS, Power GG, Blood AB. L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation. Redox Biol. 2019 09; 26:101238.

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Hall PE, Shepherd STC, Brown J, Larkin J, Jones R, Ralph C, Hawkins R, Chowdhury S, Boleti E, Bahl A, Fife K, Webb A, Crabb SJ, Geldart T, Hill R, Dunlop J, McLaren D, Ackerman C, Wimalasingham A, Beltran L, Nathan P, Powles T. Radiological Response Heterogeneity Is of Prognostic Significance in Metastatic Renal Cell Carcinoma Treated with Vascular Endothelial Growth Factor-targeted Therapy. Eur Urol Focus. 2020 09 15; 6(5):999-1005.

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Sun M, Yang Z. Metabolomic Studies of Live Single Cancer Stem Cells Using Mass Spectrometry. Anal Chem. 2019 02 05; 91(3):2384-2391.

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Tran TD, Wilson BAP, Henrich CJ, Staudt LM, Krumpe LRH, Smith EA, King J, Wendt KL, Stchigel AM, Miller AN, Cichewicz RH, O'Keefe BR, Gustafson KR. Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities. J Nat Prod. 2019 01 25; 82(1):154-162.

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Harper AR, Le AT, Mather T, Burgett A, Berry W, Summers JA. Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes. Bioorg Med Chem. 2018 12 01; 26(22):5766-5779.

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