Enzyme Inhibitors

"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Descriptor ID	D004791
MeSH Number(s)	D27.505.519.389
Concept/Terms	Enzyme Inhibitors Enzyme Inhibitors Inhibitors, Enzyme

Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]

Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.

Bar chart showing 188 publications over 27 distinct years, with a maximum of 16 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	0	3
1996	0	5	5
1997	2	5	7
1998	1	3	4
1999	5	4	9
2000	1	3	4
2001	2	11	13
2002	4	12	16
2003	1	8	9
2004	2	9	11
2005	3	3	6
2006	3	5	8
2007	3	9	12
2008	2	10	12
2009	6	2	8
2010	2	5	7
2011	2	5	7
2012	2	2	4
2013	4	6	10
2014	1	3	4
2015	2	5	7
2016	4	1	5
2017	2	2	4
2018	2	0	2
2019	4	2	6
2020	2	2	4
2021	1	0	1

Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.

Herlea-Pana O, Eeda V, Undi RB, Lim HY, Wang W. Pharmacological Inhibition of Inositol-Requiring Enzyme 1a RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021; 12:749879.

View in: PubMed
Takebe N, Naqash AR, O'Sullivan Coyne G, Kummar S, Do K, Bruns A, Juwara L, Zlott J, Rubinstein L, Piekarz R, Sharon E, Streicher H, Mittra A, Miller SB, Ji J, Wilsker D, Kinders RJ, Parchment RE, Chen L, Chang TC, Das B, Mugundu G, Doroshow JH, Chen AP. Safety, Antitumor Activity, and Biomarker Analysis in a Phase I Trial of the Once-daily Wee1 Inhibitor Adavosertib (AZD1775) in Patients with Advanced Solid Tumors. Clin Cancer Res. 2021 07 15; 27(14):3834-3844.

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Karsten W, Thomas LM, Fleming C, Seabourn P, Bruxvoort C, Chooback L. Kinetic, spectral, and structural studies of the slow-binding inhibition of the Escherichia coli dihydrodipicolinate synthase by 2, 4-oxo-pentanoic acid. Arch Biochem Biophys. 2021 05 15; 702:108819.

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Terzyan SS, Nguyen LT, Burgett AWG, Heroux A, Smith CA, You Y, Hanigan MH. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J Biol Chem. 2021 Jan-Jun; 296:100066.

View in: PubMed
Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.

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Pederson PJ, Cai S, Carver C, Powell DR, Risinger AL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. J Nat Prod. 2020 07 24; 83(7):2269-2280.

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Muddala NP, White JC, Nammalwar B, Pratt I, Thomas LM, Bunce RA, Berlin KD, Bourne CR. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.

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Buonpane C, Yuan C, Wood D, Ares G, Klonoski SC, Hunter CJ. ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2020 04 01; 318(4):G781-G792.

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Csiszar A, Yabluchanskiy A, Ungvari A, Ungvari Z, Tarantini S. Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice. Geroscience. 2019 10; 41(5):609-617.

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Hendricson A, Umlauf S, Choi JY, Thekkiniath J, Surovtseva YV, Fuller KK, Reynolds TB, Voelker DR, Ben Mamoun C. High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay. J Biol Chem. 2019 08 09; 294(32):12146-12156.

View in: PubMed

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