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Julia V Busik

TitleProf & Chair
InstitutionUniversity of Oklahoma Health Sciences Center
AddressBSEB 328B
941 Stanton L Young Blvd
Oklahoma City OK 73104
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    R01EY030766     (BUSIK, JULIA V)Aug 1, 2019 - Jun 30, 2023
    Anti-ceramide immunotherapy for diabetic retinopathy
    Role: Principal Investigator

    R01EY028049     (PROSHLYAKOV, DENIS A)Apr 1, 2018 - Mar 31, 2022
    Ceramide-mediated mitochondrial damage in diabetic retinopathy investigated by novel microfluidic O2 sensing and bio-mimetic electrochemistry
    Role: Co-Principal Investigator

    R01EY025383     (BUSIK, JULIA V;GRANT, MARIA BARTOLOMEO ;PIKULEVA, IRINA A)Sep 1, 2015 - Aug 31, 2025
    Cholesterol homeostasis in pathogenesis of DR
    Role: Principal Investigator

    R01EY016077     (BUSIK, JULIA V)Dec 1, 2004 - Jun 30, 2026
    Dyslipidemia and Diabetic Retinopathy
    Role: Principal Investigator

    R21DK065014     (BUSIK, JULIA V)Jun 15, 2003 - May 31, 2006
    Dyslipidemia and retinal endothelial cell dysfunction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hammer SS, Dorweiler TF, McFarland D, Adu-Agyeiwaah Y, Mast N, El-Darzi N, Fortmann SD, Nooti S, Agrawal DK, Pikuleva IA, Abela GS, Grant MB, Busik JV. Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy. Diabetologia. 2023 09; 66(9):1705-1718. PMID: 37311879; PMCID: PMC10390399.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Adu-Agyeiwaah Y, Vieira CP, Asare-Bediako B, Li Calzi S, DuPont M, Floyd J, Boye S, Chiodo V, Busik JV, Grant MB. Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes. Transl Vis Sci Technol. 2023 04 03; 12(4):20. PMID: 37070938; PMCID: PMC10123324.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Prasad R, Adu-Agyeiwaah Y, Floyd JL, Asare-Bediako B, Li Calzi S, Chakraborty D, Harbour A, Rohella A, Busik JV, Li Q, Grant MB. Sustained ACE2 Expression by Probiotic Improves Integrity of Intestinal Lymphatics and Retinopathy in Type 1 Diabetic Model. J Clin Med. 2023 Feb 23; 12(5). PMID: 36902558; PMCID: PMC10003436.
      Citations: 2     
    4. Busik JV, Decot H, Lin AB, Lydic TA. Untargeted Analysis of Lipids Containing Very Long Chain Fatty Acids in Retina and Retinal Tight Junctions. Methods Mol Biol. 2023; 2625:269-290. PMID: 36653650.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Lydic TA, Busik JV. Diabetes Retinopathy: New Ways to Detect and Treat. Methods Mol Biol. 2023; 2592:89-100. PMID: 36507987.
      Citations:    Fields:    Translation:Animals
    6. El-Darzi N, Mast N, Hammer SS, Dorweiler TF, Busik JV, Pikuleva IA. 2-Hydroxypropyl-?-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis. J Lipid Res. 2023 02; 64(2):100323. PMID: 36586438; PMCID: PMC9883287.
      Citations:    Fields:    Translation:Animals
    7. Jenkins AJ, Grant MB, Busik JV. Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies. Diabetologia. 2022 04; 65(4):587-603. PMID: 35149880; PMCID: PMC9377536.
      Citations: 7     Fields:    Translation:Humans
    8. Hammer SS, Vieira CP, McFarland D, Sandler M, Levitsky Y, Dorweiler TF, Lydic TA, Asare-Bediako B, Adu-Agyeiwaah Y, Sielski MS, Dupont M, Longhini AL, Li Calzi S, Chakraborty D, Seigel GM, Proshlyakov DA, Grant MB, Busik JV. Fasting and fasting-mimicking treatment activate SIRT1/LXRa and alleviate diabetes-induced systemic and microvascular dysfunction. Diabetologia. 2021 07; 64(7):1674-1689. PMID: 33770194; PMCID: PMC8236268.
      Citations: 20     Fields:    Translation:AnimalsCells
    9. Busik JV. Lipid metabolism dysregulation in diabetic retinopathy. J Lipid Res. 2021; 62:100017. PMID: 33581416; PMCID: PMC7892987.
      Citations: 30     Fields:    
    10. Vieira CP, Fortmann SD, Hossain M, Longhini AL, Hammer SS, Asare-Bediako B, Crossman DK, Sielski MS, Adu-Agyeiwaah Y, Dupont M, Floyd JL, Li Calzi S, Lydic T, Welner RS, Blanchard GJ, Busik JV, Grant MB. Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes. JCI Insight. 2020 07 09; 5(13). PMID: 32641586; PMCID: PMC7406260.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Levitsky Y, Hammer SS, Fisher KP, Huang C, Gentles TL, Pegouske DJ, Xi C, Lydic TA, Busik JV, Proshlyakov DA. Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes. Int J Mol Sci. 2020 May 28; 21(11). PMID: 32481596; PMCID: PMC7312467.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Qi X, Mitter SK, Yan Y, Busik JV, Grant MB, Boulton ME. Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina. Cells. 2020 04 07; 9(4). PMID: 32272782; PMCID: PMC7226792.
      Citations: 21     Fields:    Translation:HumansAnimals
    13. Huang C, Fisher KP, Hammer SS, Busik JV. Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition. Int J Mol Sci. 2020 Mar 01; 21(5). PMID: 32121610; PMCID: PMC7084203.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Levitsky Y, Pegouske DJ, Hammer SS, Frantz NL, Fisher KP, Muchnik AB, Saripalli AR, Kirschner P, Bazil JN, Busik JV, Proshlyakov DA. Micro-respirometry of whole cells and isolated mitochondria. RSC Adv. 2019; 9(57):33257-33267. PMID: 32123561; PMCID: PMC7051014.
      Citations: 7     
    15. Saadane A, Mast N, Trichonas G, Chakraborty D, Hammer S, Busik JV, Grant MB, Pikuleva IA. Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal. Am J Pathol. 2019 02; 189(2):405-425. PMID: 30448403; PMCID: PMC6360352.
      Citations: 23     Fields:    Translation:AnimalsCells
    16. Agbaga MP, Merriman DK, Brush RS, Lydic TA, Conley SM, Naash MI, Jackson S, Woods AS, Reid GE, Busik JV, Anderson RE. Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors. J Lipid Res. 2018 09; 59(9):1586-1596. PMID: 29986998.
      Citations: 33     Fields:    Translation:AnimalsCells
    17. Huang C, Fisher KP, Hammer SS, Navitskaya S, Blanchard GJ, Busik JV. Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway. Diabetes. 2018 08; 67(8):1639-1649. PMID: 29866771; PMCID: PMC6054433.
      Citations: 48     Fields:    Translation:AnimalsCells
    18. Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB. Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice. Diabetes. 2018 09; 67(9):1867-1879. PMID: 29712667; PMCID: PMC6110320.
      Citations: 141     Fields:    Translation:AnimalsCells
    19. Shaw LC, Li Calzi S, Li N, Moldovan L, Sengupta-Caballero N, Quigley JL, Ivan M, Jun B, Bazan NG, Boulton ME, Busik J, Neu J, Grant MB. Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity. Invest Ophthalmol Vis Sci. 2018 02 01; 59(2):858-869. PMID: 29490339; PMCID: PMC5815421.
      Citations: 9     Fields:    Translation:Animals
    20. Malek G, Busik J, Grant MB, Choudhary M. Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov. 2018 04; 13(4):359-377. PMID: 29382242; PMCID: PMC6192033.
      Citations: 25     Fields:    Translation:HumansAnimals
    21. Kady NM, Liu X, Lydic TA, Syed MH, Navitskaya S, Wang Q, Hammer SS, O'Reilly S, Huang C, Seregin SS, Amalfitano A, Chiodo VA, Boye SL, Hauswirth WW, Antonetti DA, Busik JV. ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes. 2018 04; 67(4):769-781. PMID: 29362226; PMCID: PMC5860862.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    22. Bhatwadekar AD, Duan Y, Korah M, Thinschmidt JS, Hu P, Leley SP, Caballero S, Shaw L, Busik J, Grant MB. Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation. Vision Res. 2017 10; 139:211-220. PMID: 29042190; PMCID: PMC6335030.
      Citations: 15     Fields:    Translation:HumansCells
    23. Hunt AMA, Gibson JA, Larrivee CL, O'Reilly S, Navitskaya S, Busik JV, Waters CM. Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model. J Vis Exp. 2017 10 10; (128). PMID: 29053700; PMCID: PMC5752399.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    24. Hammer SS, Beli E, Kady N, Wang Q, Wood K, Lydic TA, Malek G, Saban DR, Wang XX, Hazra S, Levi M, Busik JV, Grant MB. The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. EBioMedicine. 2017 Aug; 22:181-190. PMID: 28774737; PMCID: PMC5552206.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    25. Agostinho Hunt AM, Gibson JA, Larrivee CL, O'Reilly S, Navitskaya S, Needle DB, Abramovitch RB, Busik JV, Waters CM. A bioluminescent Pseudomonas aeruginosa wound model reveals increased mortality of type 1 diabetic mice to biofilm infection. J Wound Care. 2017 Jul 01; 26(Sup7):S24-S33. PMID: 28704171.
      Citations: 9     Fields:    Translation:AnimalsCells
    26. Hammer SS, Busik JV. The role of dyslipidemia in diabetic retinopathy. Vision Res. 2017 10; 139:228-236. PMID: 28545981; PMCID: PMC5702582.
      Citations: 38     Fields:    Translation:Humans
    27. Hassan I, Luo Q, Majumdar S, Dominguez JM, Busik JV, Bhatwadekar AD. Tumor Necrosis Factor Alpha (TNF-a) Disrupts Kir4.1 Channel Expression Resulting in M?ller Cell Dysfunction in the Retina. Invest Ophthalmol Vis Sci. 2017 05 01; 58(5):2473-2482. PMID: 28460049.
      Citations: 11     Fields:    Translation:AnimalsCells
    28. Bhatwadekar AD, Beli E, Diao Y, Chen J, Luo Q, Alex A, Caballero S, Dominguez JM, Salazar TE, Busik JV, Segal MS, Grant MB. Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury. Am J Pathol. 2017 Jun; 187(6):1426-1435. PMID: 28432873; PMCID: PMC5455061.
      Citations: 18     Fields:    Translation:AnimalsCells
    29. Kady N, Yan Y, Salazar T, Wang Q, Chakravarthy H, Huang C, Beli E, Navitskaya S, Grant M, Busik J. Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes. J Clin Lipidol. 2017 May - Jun; 11(3):694-703. PMID: 28457994; PMCID: PMC5492962.
      Citations: 15     Fields:    Translation:HumansCells
    30. Blanchard GJ, Busik JV. Interplay between Endothelial Cell Cytoskeletal Rigidity and Plasma Membrane Fluidity. Biophys J. 2017 03 14; 112(5):831-833. PMID: 28297642; PMCID: PMC5355480.
      Citations: 5     Fields:    Translation:Cells
    31. Ho NT, Busik JV, Resau JH, Paneth N, Khoo SK. Effect of storage time on gene expression data acquired from unfrozen archived newborn blood spots. Mol Genet Metab. 2016 11; 119(3):207-213. PMID: 27553879; PMCID: PMC5083152.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    32. Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic TA, Chen YE, Yin KJ, Powell FL, Martin PM, Grant MB, Busik JV. Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy. EBioMedicine. 2016 Sep; 11:138-150. PMID: 27531575; PMCID: PMC5049929.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    33. Chakravarthy H, Beli E, Navitskaya S, O'Reilly S, Wang Q, Kady N, Huang C, Grant MB, Busik JV. Imbalances in Mobilization and Activation of Pro-Inflammatory and Vascular Reparative Bone Marrow-Derived Cells in Diabetic Retinopathy. PLoS One. 2016; 11(1):e0146829. PMID: 26760976; PMCID: PMC4711951.
      Citations: 26     Fields:    Translation:AnimalsCells
    34. Chakravarthy H, Navitskaya S, O'Reilly S, Gallimore J, Mize H, Beli E, Wang Q, Kady N, Huang C, Blanchard GJ, Grant MB, Busik JV. Role of Acid Sphingomyelinase in Shifting the Balance Between Proinflammatory and Reparative Bone Marrow Cells in Diabetic Retinopathy. Stem Cells. 2016 Apr; 34(4):972-83. PMID: 26676316; PMCID: PMC5088619.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    35. Bhatwadekar AD, Duan Y, Chakravarthy H, Korah M, Caballero S, Busik JV, Grant MB. Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy. Stem Cells. 2016 Feb; 34(2):405-17. PMID: 26502796; PMCID: PMC5125377.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    36. Busik JV, Grant MB. Wnting out ocular neovascularization: using nanoparticle delivery of very-low density lipoprotein receptor extracellular domain as Wnt pathway inhibitor in the retina. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1046-7. PMID: 25903649; PMCID: PMC4428600.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    37. Lydic TA, Busik JV, Reid GE. A monophasic extraction strategy for the simultaneous lipidome analysis of polar and nonpolar retina lipids. J Lipid Res. 2014 Aug; 55(8):1797-809. PMID: 24879804; PMCID: PMC4109773.
      Citations: 37     Fields:    Translation:Animals
    38. Wang Q, Bozack SN, Yan Y, Boulton ME, Grant MB, Busik JV. Regulation of retinal inflammation by rhythmic expression of MiR-146a in diabetic retina. Invest Ophthalmol Vis Sci. 2014 May 27; 55(6):3986-94. PMID: 24867582; PMCID: PMC4073658.
      Citations: 39     Fields:    Translation:AnimalsCells
    39. Wang Q, Tikhonenko M, Bozack SN, Lydic TA, Yan L, Panchy NL, McSorley KM, Faber MS, Yan Y, Boulton ME, Grant MB, Busik JV. Changes in the daily rhythm of lipid metabolism in the diabetic retina. PLoS One. 2014; 9(4):e95028. PMID: 24736612; PMCID: PMC3988159.
      Citations: 20     Fields:    Translation:Animals
    40. Bennett LD, Brush RS, Chan M, Lydic TA, Reese K, Reid GE, Busik JV, Elliott MH, Anderson RE. Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest Ophthalmol Vis Sci. 2014 Apr 10; 55(5):3150-7. PMID: 24722693.
      Citations: 26     Fields:    Translation:AnimalsCells
    41. Busik JV, Grant MB. Aldose reductase meets histone acetylation: a new role for an old player. Diabetes. 2014 Feb; 63(2):402-4. PMID: 24464719; PMCID: PMC3900550.
      Citations:    Fields:    Translation:HumansAnimals
    42. Yan Y, Salazar TE, Dominguez JM, Nguyen DV, Li Calzi S, Bhatwadekar AD, Qi X, Busik JV, Boulton ME, Grant MB. Dicer expression exhibits a tissue-specific diurnal pattern that is lost during aging and in diabetes. PLoS One. 2013; 8(11):e80029. PMID: 24244599; PMCID: PMC3820540.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    43. Hu P, Thinschmidt JS, Yan Y, Hazra S, Bhatwadekar A, Caballero S, Salazar T, Miyan JA, Li W, Derbenev A, Zsombok A, Tikhonenko M, Dominguez JM, McGorray SP, Saban DR, Boulton ME, Busik JV, Raizada MK, Chan-Ling T, Grant MB. CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol. 2013 Nov; 183(5):1608-20. PMID: 24160325; PMCID: PMC3814523.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    44. Tikhonenko M, Lydic TA, Opreanu M, Li Calzi S, Bozack S, McSorley KM, Sochacki AL, Faber MS, Hazra S, Duclos S, Guberski D, Reid GE, Grant MB, Busik JV. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. PLoS One. 2013; 8(1):e55177. PMID: 23383097; PMCID: PMC3558503.
      Citations: 49     Fields:    Translation:AnimalsCells
    45. Ho NT, Furge K, Fu W, Busik J, Khoo SK, Lu Q, Lenski M, Wirth J, Hurvitz E, Dodge N, Resau J, Paneth N. Gene expression in archived newborn blood spots distinguishes infants who will later develop cerebral palsy from matched controls. Pediatr Res. 2013 Apr; 73(4 Pt 1):450-6. PMID: 23269123; PMCID: PMC4350763.
      Citations: 17     Fields:    Translation:HumansPHPublic Health
    46. Busik JV, Esselman WJ, Reid GE. Examining the role of lipid mediators in diabetic retinopathy. Clin Lipidol. 2012 Dec 01; 7(6):661-675. PMID: 23646066; PMCID: PMC3640872.
      Citations: 21     
    47. Bhatwadekar AD, Yan Y, Qi X, Thinschmidt JS, Neu MB, Li Calzi S, Shaw LC, Dominiguez JM, Busik JV, Lee C, Boulton ME, Grant MB. Per2 mutation recapitulates the vascular phenotype of diabetes in the retina and bone marrow. Diabetes. 2013 Jan; 62(1):273-82. PMID: 23193187; PMCID: PMC3526035.
      Citations: 39     Fields:    Translation:AnimalsCells
    48. Resau JH, Ho NT, Dykema K, Faber MS, Busik JV, Nickolov RZ, Furge KA, Paneth N, Jewell S, Khoo SK. Evaluation of sex-specific gene expression in archived dried blood spots (DBS). Int J Mol Sci. 2012; 13(8):9599-9608. PMID: 22949818; PMCID: PMC3431816.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    49. Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB. Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase). Invest Ophthalmol Vis Sci. 2011 Oct 21; 52(11):8278-86. PMID: 21931131; PMCID: PMC3208060.
      Citations: 19     Fields:    Translation:AnimalsCells
    50. Opreanu M, Tikhonenko M, Bozack S, Lydic TA, Reid GE, McSorley KM, Sochacki A, Perez GI, Esselman WJ, Kern T, Kolesnick R, Grant MB, Busik JV. The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models. Diabetes. 2011 Sep; 60(9):2370-8. PMID: 21771974; PMCID: PMC3161322.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    51. Griffitts J, Saunders D, Tesiram YA, Reid GE, Salih A, Liu S, Lydic TA, Busik JV, Kang JX, Towner RA. Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia. Biochim Biophys Acta. 2010 Oct; 1801(10):1133-44. PMID: 20620224.
      Citations: 12     Fields:    Translation:Animals
    52. Opreanu M, Lydic TA, Reid GE, McSorley KM, Esselman WJ, Busik JV. Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3253-63. PMID: 20071681; PMCID: PMC2891477.
      Citations: 42     Fields:    Translation:HumansCells
    53. Lydic TA, Renis R, Busik JV, Reid GE. Analysis of Retina and Erythrocyte Glycerophospholipid Alterations in a Rat Model of Type 1 Diabetes. JALA Charlottesv Va. 2009 Dec 01; 14(6):383-399. PMID: 20161420; PMCID: PMC2786180.
      Citations: 8     
    54. Busik JV, Tikhonenko M, Bhatwadekar A, Opreanu M, Yakubova N, Caballero S, Player D, Nakagawa T, Afzal A, Kielczewski J, Sochacki A, Hasty S, Li Calzi S, Kim S, Duclas SK, Segal MS, Guberski DL, Esselman WJ, Boulton ME, Grant MB. Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock. J Exp Med. 2009 Dec 21; 206(13):2897-906. PMID: 19934019; PMCID: PMC2806461.
      Citations: 121     Fields:    Translation:AnimalsCells
    55. Tikhonenko M, Lydic TA, Wang Y, Chen W, Opreanu M, Sochacki A, McSorley KM, Renis RL, Kern T, Jump DB, Reid GE, Busik JV. Remodeling of retinal Fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes. 2010 Jan; 59(1):219-27. PMID: 19875612; PMCID: PMC2797925.
      Citations: 76     Fields:    Translation:Animals
    56. Kielczewski JL, Jarajapu YP, McFarland EL, Cai J, Afzal A, Li Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Boulton ME, Mames RN, Chan-Ling T, Grant MB. Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation. Circ Res. 2009 Oct 23; 105(9):897-905. PMID: 19762684; PMCID: PMC3635679.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    57. Lydic TA, Busik JV, Esselman WJ, Reid GE. Complementary precursor ion and neutral loss scan mode tandem mass spectrometry for the analysis of glycerophosphatidylethanolamine lipids from whole rat retina. Anal Bioanal Chem. 2009 May; 394(1):267-75. PMID: 19277613; PMCID: PMC4112091.
      Citations: 11     Fields:    Translation:Animals
    58. Birmingham JM, Busik JV, Hansen-Smith FM, Fenton JI. Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis. 2009 Apr; 30(4):690-7. PMID: 19221001; PMCID: PMC2664456.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    59. Busik JV, Reid GE, Lydic TA. Global analysis of retina lipids by complementary precursor ion and neutral loss mode tandem mass spectrometry. Methods Mol Biol. 2009; 579:33-70. PMID: 19763470; PMCID: PMC2879063.
      Citations: 28     Fields:    Translation:Animals
    60. Yego EC, Vincent JA, Sarthy V, Busik JV, Mohr S. Differential regulation of high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation in M?ller cells by IL-1beta and IL-6. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1920-8. PMID: 19060282.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    61. Haak PT, Busik JV, Kort EJ, Tikhonenko M, Paneth N, Resau JH. Archived unfrozen neonatal blood spots are amenable to quantitative gene expression analysis. Neonatology. 2009; 95(3):210-6. PMID: 18799893; PMCID: PMC2693916.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    62. Li Calzi S, Purich DL, Chang KH, Afzal A, Nakagawa T, Busik JV, Agarwal A, Segal MS, Grant MB. Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes. Diabetes. 2008 Sep; 57(9):2488-94. PMID: 18559661; PMCID: PMC2518501.
      Citations: 31     Fields:    Translation:HumansCells
    63. Busik JV, Mohr S, Grant MB. Hyperglycemia-induced reactive oxygen species toxicity to endothelial cells is dependent on paracrine mediators. Diabetes. 2008 Jul; 57(7):1952-65. PMID: 18420487; PMCID: PMC2453610.
      Citations: 146     Fields:    Translation:HumansCells
    64. Chen W, Jump DB, Esselman WJ, Busik JV. Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):18-26. PMID: 17197511; PMCID: PMC1975816.
      Citations: 47     Fields:    Translation:HumansCells
    65. Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair MG, Nair M, Peters JM, Peters JM, Busik JV, Busik J, Olson LK, Jump DB. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res. 2006 Sep; 47(9):2028-41. PMID: 16790840; PMCID: PMC2764365.
      Citations: 131     Fields:    Translation:HumansAnimals
    66. Chen W, Esselman WJ, Jump DB, Busik JV. Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4342-7. PMID: 16249517; PMCID: PMC1378111.
      Citations: 73     Fields:    Translation:HumansCells
    67. Wang Y, Botolin D, Christian B, Busik J, Xu J, Jump DB. Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. J Lipid Res. 2005 Apr; 46(4):706-15. PMID: 15654130; PMCID: PMC2430181.
      Citations: 97     Fields:    Translation:Animals
    68. Chen W, Jump DB, Grant MB, Esselman WJ, Busik JV. Dyslipidemia, but not hyperglycemia, induces inflammatory adhesion molecules in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 2003 Nov; 44(11):5016-22. PMID: 14578429.
      Citations: 42     Fields:    Translation:HumansCells
    69. Gorovits N, Cui L, Busik JV, Ranalletta M, Hauguel de-Mouzon S, Charron MJ. Regulation of hepatic GLUT8 expression in normal and diabetic models. Endocrinology. 2003 May; 144(5):1703-11. PMID: 12697674.
      Citations: 18     Fields:    Translation:Animals
    70. Busik JV, Olson LK, Grant MB, Henry DN. Glucose-induced activation of glucose uptake in cells from the inner and outer blood-retinal barrier. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2356-63. PMID: 12091438.
      Citations: 16     Fields:    Translation:HumansCells
    71. Ishihara Y, Sakurai T, Habara Y, Busik JV, Kanno T, Terakawa S. Exocytosis in the dissociated pancreatic acinar cells of the guinea pig directly visualized by VEC-DIC microscopy. Biochem Biophys Res Commun. 2000 Oct 14; 277(1):134-7. PMID: 11027653.
      Citations: 1     Fields:    Translation:AnimalsCells
    72. Henry DN, Frank RN, Hootman SR, Rood SE, Heilig CW, Busik JV. Glucose-specific regulation of aldose reductase in human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1554-60. PMID: 10798676.
      Citations: 11     Fields:    Translation:HumansCells
    73. Henry DN, Busik JV, Brosius FC, Heilig CW. Glucose transporters control gene expression of aldose reductase, PKCalpha, and GLUT1 in mesangial cells in vitro. Am J Physiol. 1999 07; 277(1):F97-104. PMID: 10409302.
      Citations: 10     Fields:    Translation:AnimalsCells
    74. Busik JV, Hootman SR, Greenidge CA, Henry DN. Glucose-specific regulation of aldose reductase in capan-1 human pancreatic duct cells In vitro. J Clin Invest. 1997 Oct 01; 100(7):1685-92. PMID: 9312166; PMCID: PMC508351.
      Citations: 8     Fields:    Translation:HumansCells
    75. Busik J, Nakamura M, Abe Y, Shibuya I, Kanno T. Effects of GABA on spontaneous [Ca2+]c dynamics and electrical properties of rat adrenal chromaffin cells. Brain Res. 1996 Nov 11; 739(1-2):97-103. PMID: 8955929.
      Citations: 5     Fields:    Translation:AnimalsCells
    76. Busik J, Habara Y, Maruyama T, Kanno T. Inhibition by a receptor-mediated Ca2+ entry blocker, SK&F 96365, of Ca2+ and secretory responses in rat pancreatic acini. Eur J Pharmacol. 1993 Nov 15; 247(3):273-81. PMID: 7508399.
      Citations: 1     Fields:    Translation:Animals
    77. Ikei N, Busik J, Habara Y, Kanno T. Competitive inhibition by procaine of carbachol-induced stimulus-secretion coupling in rat pancreatic acini. Br J Pharmacol. 1993 Oct; 110(2):603-8. PMID: 7694753; PMCID: PMC2175937.
      Citations:    Fields:    Translation:AnimalsCells
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