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Prabhakara R Nagareddy

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Cardiology
AddressAAT 5400
800 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
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    R01HL156856     (NAGAREDDY, PRABHAKARA REDDY)Jul 1, 2022 - Jun 30, 2027
    NIH
    A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injury
    Role: Principal Investigator
    TPA970002     (Nagareddy)Jul 1, 2022 - Jun 30, 2025
    AHA
    Harnessing the potential of an endogenous anti-inflammatory mechanism to mitigate cardiac inflammation and heart failure
    Role: PI
    R01HL137799     (NAGAREDDY, PRABHAKARA REDDY)Apr 23, 2018 - Mar 31, 2024
    NIH
    Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular Patterns
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Das S, Varshney R, Farriester JW, Kyere-Davies G, Martinez AE, Hill K, Kinter M, Mullen GP, Nagareddy PR, Rudolph MC. NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation. bioRxiv. 2024 Sep 09. PMID: 39314382; PMCID: PMC11419096.
      Citations:    
    2. Hill K, Mullen GP, Nagareddy P, Zimmerman K, Rudolph MC. Key Questions and Gaps in Understanding Adipose Tissue Macrophages and Early-Life Metabolic Programming. Am J Physiol Endocrinol Metab. 2024 Aug 22. PMID: 39171752.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Shantaram D, Hoyd R, Blaszczak AM, Antwi L, Jalilvand A, Wright VP, Liu J, Smith AJ, Bradley D, Lafuse W, Liu Y, Williams NF, Snyder O, Wheeler C, Needleman B, Brethauer S, Noria S, Renton D, Perry KA, Nagareddy P, Wozniak D, Mahajan S, Rana PSJB, Pietrzak M, Schlesinger LS, Spakowicz DJ, Hsueh WA. Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils. Nat Commun. 2024 Jun 27; 15(1):5434. PMID: 38937454; PMCID: PMC11211470.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Kanuri B, Sreejit G, Biswas P, Murphy AJ, Nagareddy PR. Macrophage heterogeneity in myocardial infarction: Evolution and implications for diverse therapeutic approaches. iScience. 2024 Jul 19; 27(7):110274. PMID: 39040061; PMCID: PMC11261154.
      Citations:    
    5. Traughber CA, Timinski K, Prince A, Bhandari N, Neupane K, Khan MR, Opoku E, Opoku E, Brubaker G, Shin J, Hong J, Kanuri B, Ertugral EG, Nagareddy PR, Kothapalli CR, Cherepanova O, Smith JD, Gulshan K. Disulfiram Reduces Atherosclerosis and Enhances Efferocytosis, Autophagy, and Atheroprotective Gut Microbiota in Hyperlipidemic Mice. J Am Heart Assoc. 2024 Apr 02; e033881. PMID: 38563369.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Kanuri B, Biswas P, Dahdah A, Murphy AJ, Nagareddy PR. Impact of age and sex on myelopoiesis and inflammation during myocardial infarction. J Mol Cell Cardiol. 2023 Dec 08. PMID: 38163742.
      Citations: 1     Fields:    Translation:HumansCells
    7. Kumar N, Pestrak MJ, Wu Q, Ahumada OS, Dellos-Nolan S, Saljoughian N, Shukla RK, Mitchem CF, Nagareddy PR, Ganesan LP, William LP, Wozniak DJ, Rajaram MVS. Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction. PLoS Pathog. 2023 08; 19(8):e1011573. PMID: 37624851; PMCID: PMC10484443.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Crocco P, Vecchie D, Gopalkrishna S, Dato S, Passarino G, Young ME, Nagareddy PR, Rose G, De Luca M. Correction: Syndecan-4 as a genetic determinant of the metabolic syndrome. Diabetol Metab Syndr. 2023 Aug 03; 15(1):166. PMID: 37537661; PMCID: PMC10399039.
      Citations:    
    9. Crocco P, Vecchie D, Gopalkrishna S, Dato S, Passarino G, Young ME, Nagareddy PR, Rose G, De Luca M. Syndecan-4 as a genetic determinant of the metabolic syndrome. Diabetol Metab Syndr. 2023 Jul 17; 15(1):156. PMID: 37461091; PMCID: PMC10351106.
      Citations: 2     
    10. Moellering DR, Smith-Johnston K, Kelley C, Sammy MJ, Benedict J, Brock G, Johnson J, Baskin KK, Jarjour WN, Belury MA, Reiser PJ, Nagareddy PR, Hanaoka BY. Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study. Arthritis Res Ther. 2023 05 20; 25(1):85. PMID: 37210569; PMCID: PMC10199606.
      Citations: 1     Fields:    Translation:HumansCells
    11. Dragoljevic D, Lee MKS, Pernes G, Morgan PK, Louis C, Shihata W, Huynh K, Kochetkova AA, Bell PW, Mellett NA, Meikle PJ, Lancaster GI, Kraakman MJ, Nagareddy PR, Hanaoka BY, Wicks IP, Murphy AJ. Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis. Clin Transl Immunology. 2023; 12(4):e1446. PMID: 37091327; PMCID: PMC10113696.
      Citations: 1     
    12. Kawaguchi N, Bruno A, Nagareddy PR, Nakanishi T, Rajaram MVS, Spinetti G. Editorial: The role of inflammation, stem cells and progenitor cells in cardiovascular repair. Front Cardiovasc Med. 2023; 10:1195863. PMID: 37144059; PMCID: PMC10151808.
      Citations:    
    13. Nagareddy PR, Murphy AJ. TP53 clonal hematopoiesis promotes atherosclerosis. Nat Cardiovasc Res. 2023 Feb; 2(2):102-103. PMID: 39196052.
      Citations:    
    14. Nagareddy PR, Murphy AJ. Nature Cardiovascular Research. TP53 clonal hematopoiesis promotes atherosclerosis . 2023; 2:102-103.
    15. Dahdah A, Jaggers RM, Sreejit G, Johnson J, Kanuri B, Murphy AJ, Nagareddy PR. Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk. Cells. 2022 10 11; 11(20). PMID: 36291057; PMCID: PMC9600209.
      Citations: 4     Fields:    Translation:Animals
    16. Sreejit G, Johnson J, Jaggers RM, Dahdah A, Murphy AJ, Hanssen NMJ, Nagareddy PR. Neutrophils in cardiovascular disease: warmongers, peacemakers, or both? Cardiovasc Res. 2022 09 20; 118(12):2596-2609. PMID: 34534269; PMCID: PMC9890471.
      Citations: 15     Fields:    Translation:HumansCells
    17. Nagareddy PR, Sreejit G. Response by Nagareddy and Sreejit to Letter Regarding Article, "Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction-Induced Granulopoiesis". Circulation. 2022 05 10; 145(19):e1035-e1036. PMID: 35533219; PMCID: PMC9191749.
      Citations:    Fields:    Translation:HumansCells
    18. Araujo N, Sledziona J, Noothi SK, Burikhanov R, Hebbar N, Ganguly S, Shrestha-Bhattarai T, Zhu B, Katz WS, Zhang Y, Taylor BS, Liu J, Chen L, Weiss HL, He D, Wang C, Morris AJ, Cassis LA, Nikolova-Karakashian M, Nagareddy PR, Melander O, Evers BM, Kern PA, Rangnekar VM. Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity. Front Oncol. 2022; 12:860446. PMID: 35425699; PMCID: PMC9004617.
      Citations: 2     
    19. Nagareddy PR, Sreejit G. Letter by Nagareddy and Sreejit Regarding Article, "Interleukin-1a Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease". Circulation. 2022 03 08; 145(10):e762-e763. PMID: 35254918; PMCID: PMC8909356.
      Citations:    Fields:    Translation:HumansCells
    20. Dahdah A, Johnson J, Gopalkrishna S, Jaggers RM, Webb D, Murphy AJ, Hanssen NMJ, Hanaoka BY, Nagareddy PR. Neutrophil Migratory Patterns: Implications for Cardiovascular Disease. Front Cell Dev Biol. 2022; 10:795784. PMID: 35309915; PMCID: PMC8924299.
      Citations: 3     
    21. Sreejit G, Nooti SK, Jaggers RM, Athmanathan B, Ho Park K, Al-Sharea A, Johnson J, Dahdah A, Lee MKS, Ma J, Murphy AJ, Nagareddy PR. Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction-Induced Granulopoiesis. Circulation. 2022 01 04; 145(1):31-44. PMID: 34788059; PMCID: PMC8716427.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    22. Johnson J, Jaggers RM, Gopalkrishna S, Dahdah A, Murphy AJ, Hanssen NMJ, Nagareddy PR. Oxidative Stress in Neutrophils: Implications for Diabetic Cardiovascular Complications. Antioxid Redox Signal. 2022 04; 36(10-12):652-666. PMID: 34148367; PMCID: PMC9057880.
      Citations: 14     Fields:    Translation:HumansCells
    23. Cooney OD, Nagareddy PR, Murphy AJ, Lee MKS. Healthy Gut, Healthy Bones: Targeting the Gut Microbiome to Promote Bone Health. Front Endocrinol (Lausanne). 2020; 11:620466. PMID: 33679604; PMCID: PMC7933548.
      Citations: 22     Fields:    Translation:HumansAnimals
    24. Lee MKS, Kraakman MJ, Dragoljevic D, Hanssen NMJ, Flynn MC, Al-Sharea A, Sreejit G, Bertuzzo-Veiga C, Cooney OD, Baig F, Morriss E, Cooper ME, Josefsson EC, Kile BT, Nagareddy PR, Murphy AJ. Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes. Arterioscler Thromb Vasc Biol. 2021 03; 41(3):1167-1178. PMID: 33441028; PMCID: PMC7904582.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    25. Hanssen NMJ, Spaetgens B, Nagareddy PR, Murphy AJ. DAMPening Mortality in COVID-19: Therapeutic Insights From Basic Cardiometabolic Studies on S100A8/A9. Circulation. 2021 03 09; 143(10):971-973. PMID: 33434052; PMCID: PMC7940571.
      Citations: 5     Fields:    Translation:HumansCells
    26. Sreejit G, Fleetwood AJ, Murphy AJ, Nagareddy PR. Origins and diversity of macrophages in health and disease. Clin Transl Immunology. 2020; 9(12):e1222. PMID: 33363732; PMCID: PMC7750014.
      Citations: 30     
    27. Fadini GP, Mehta A, Dhindsa DS, Bonora BM, Sreejit G, Nagareddy P, Quyyumi AA. Circulating stem cells and cardiovascular outcomes: from basic science to the clinic. Eur Heart J. 2020 11 21; 41(44):4271-4282. PMID: 31891403; PMCID: PMC7825095.
      Citations: 37     Fields:    Translation:HumansCells
    28. Dragoljevic D, Lee MKS, Louis C, Shihata W, Kraakman MJ, Hansen J, Masters SL, Hanaoka BY, Nagareddy PR, Lancaster GI, Wicks IP, Murphy AJ. Inhibition of interleukin-1? signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis. Clin Transl Immunology. 2020; 9(11):e1206. PMID: 33204425; PMCID: PMC7652637.
      Citations: 7     
    29. Sreejit G, Abdel Latif A, Murphy AJ, Nagareddy PR. Emerging roles of neutrophil-borne S100A8/A9 in cardiovascular inflammation. Pharmacol Res. 2020 11; 161:105212. PMID: 32991974; PMCID: PMC7755830.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    30. Hanssen NMJ, Kraakman MJ, Flynn MC, Nagareddy PR, Schalkwijk CG, Murphy AJ. Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes? Front Cardiovasc Med. 2020; 7:570553. PMID: 33195459; PMCID: PMC7530333.
      Citations: 19     
    31. Nagareddy PR, Sreejit G, Abo-Aly M, Jaggers RM, Chelvarajan L, Johnson J, Pernes G, Athmanathan B, Abdel-Latif A, Murphy AJ. NETosis Is Required for S100A8/A9-Induced Granulopoiesis After Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2805-2807. PMID: 32878477; PMCID: PMC7578110.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    32. Sreejit G, Nagareddy PR. Response by Sreejit and Nagareddy to Letter Regarding Article, "Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction". Circulation. 2020 09; 142(9):e125-e126. PMID: 32866066; PMCID: PMC7594618.
      Citations: 2     Fields:    Translation:HumansCells
    33. Lee MKS, Sreejit G, Nagareddy PR, Murphy AJ. Attack of the NETs! NETosis primes IL-1?-mediated inflammation in diabetic foot ulcers. Clin Sci (Lond). 2020 06 26; 134(12):1399-1401. PMID: 32556177.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    34. Flynn MC, Kraakman MJ, Tikellis C, Lee MKS, Hanssen NMJ, Kammoun HL, Pickering RJ, Dragoljevic D, Al-Sharea A, Barrett TJ, Hortle F, Byrne FL, Olzomer E, McCarthy DA, Schalkwijk CG, Forbes JM, Hoehn K, Makowski L, Lancaster GI, El-Osta A, Fisher EA, Goldberg IJ, Cooper ME, Nagareddy PR, Thomas MC, Murphy AJ. Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis. Circ Res. 2020 09 11; 127(7):877-892. PMID: 32564710; PMCID: PMC7486277.
      Citations: 62     Fields:    Translation:AnimalsCells
    35. Sreejit G, Flynn MC, Patil M, Krishnamurthy P, Murphy AJ, Nagareddy PR. S100 family proteins in inflammation and beyond. Adv Clin Chem. 2020; 98:173-231. PMID: 32564786.
      Citations: 36     Fields:    Translation:HumansAnimals
    36. Asare-Bediako B, Noothi SK, Li Calzi S, Athmanathan B, Vieira CP, Adu-Agyeiwaah Y, Dupont M, Jones BA, Wang XX, Chakraborty D, Levi M, Nagareddy PR, Grant MB. Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes. Cells. 2020 02 18; 9(2). PMID: 32085589; PMCID: PMC7072836.
      Citations: 29     Fields:    Translation:Animals
    37. Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, Quaife-Ryan GA, Al-Sharea A, Pernes G, Dragoljevic D, Lal H, Schroder K, Hanaoka BY, Raman C, Grant MB, Hudson JE, Smyth SS, Porrello ER, Murphy AJ, Nagareddy PR. Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction. Circulation. 2020 03 31; 141(13):1080-1094. PMID: 31941367; PMCID: PMC7122461.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    38. De Luca M, Vecchie' D, Athmanathan B, Gopalkrishna S, Valcin JA, Swain TM, Sertie R, Wekesa K, Rowe GC, Bailey SM, Nagareddy PR. Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet. Nutrients. 2019 Nov 18; 11(11). PMID: 31752080; PMCID: PMC6893658.
      Citations: 8     Fields:    Translation:AnimalsCells
    39. Duan Y, Prasad R, Feng D, Beli E, Li Calzi S, Longhini ALF, Lamendella R, Floyd JL, Dupont M, Noothi SK, Sreejit G, Athmanathan B, Wright J, Jensen AR, Oudit GY, Markel TA, Nagareddy PR, Obukhov AG, Grant MB. Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency. Circ Res. 2019 11 08; 125(11):969-988. PMID: 31610731; PMCID: PMC7056264.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    40. Flynn MC, Pernes G, Lee MKS, Nagareddy PR, Murphy AJ. Monocytes, Macrophages, and Metabolic Disease in Atherosclerosis. Front Pharmacol. 2019; 10:666. PMID: 31249530; PMCID: PMC6584106.
      Citations: 45     
    41. Sreejit G, Nooti SK, Athmanathan B, Nagareddy PR. S100A8/A9 in Myocardial Infarction. Methods Mol Biol. 2019; 1929:739-754. PMID: 30710308.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    42. Al-Sharea A, Lee MKS, Whillas A, Michell DL, Shihata WA, Nicholls AJ, Cooney OD, Kraakman MJ, Veiga CB, Jefferis AM, Jackson K, Nagareddy PR, Lambert G, Wong CHY, Andrews KL, Head GA, Chin-Dusting J, Murphy AJ. Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis. Haematologica. 2019 03; 104(3):456-467. PMID: 30361420; PMCID: PMC6395347.
      Citations: 30     Fields:    Translation:AnimalsCells
    43. Klyachkin YM, Idris A, Rodell CB, Tripathi H, Ye S, Nagareddy P, Asfour A, Gao E, Annabathula R, Ratajczak M, Burdick JA, Abdel-Latif A. Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. Stem Cell Rev Rep. 2018 Oct; 14(5):702-714. PMID: 29948752; PMCID: PMC6119631.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Dragoljevic D, Westerterp M, Veiga CB, Nagareddy P, Murphy AJ. Disordered haematopoiesis and cardiovascular disease: a focus on myelopoiesis. Clin Sci (Lond). 2018 09 14; 132(17):1889-1899. PMID: 30185612.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    45. Dragoljevic D, Kraakman MJ, Nagareddy PR, Ngo D, Shihata W, Kammoun HL, Whillas A, Lee MKS, Al-Sharea A, Pernes G, Flynn MC, Lancaster GI, Febbraio MA, Chin-Dusting J, Hanaoka BY, Wicks IP, Murphy AJ. Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis. Eur Heart J. 2018 06 14; 39(23):2158-2167. PMID: 29905812; PMCID: PMC6001889.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    46. Nagareddy PR, Noothi SK, Flynn MC, Murphy AJ. It's reticulated: the liver at the heart of atherosclerosis. J Endocrinol. 2018 07; 238(1):R1-R11. PMID: 29720539; PMCID: PMC7065032.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    47. Al-Sharea A, Murphy AJ, Huggins LA, Hu Y, Goldberg IJ, Nagareddy PR. SGLT2 inhibition reduces atherosclerosis by enhancing lipoprotein clearance in Ldlr-/- type 1 diabetic mice. Atherosclerosis. 2018 04; 271:166-176. PMID: 29518749; PMCID: PMC7196281.
      Citations: 27     Fields:    Translation:AnimalsCells
    48. Manning JR, Chelvarajan L, Levitan BM, Withers CN, Nagareddy PR, Haggerty CM, Fornwalt BK, Gao E, Tripathi H, Abdel-Latif A, Andres DA, Satin J. Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling. JACC Basic Transl Sci. 2018 Feb; 3(1):83-96. PMID: 29732439; PMCID: PMC5931223.
      Citations: 4     
    49. Kraakman MJ, Lee MK, Al-Sharea A, Dragoljevic D, Barrett TJ, Montenont E, Basu D, Heywood S, Kammoun HL, Flynn M, Whillas A, Hanssen NM, Febbraio MA, Westein E, Fisher EA, Chin-Dusting J, Cooper ME, Berger JS, Goldberg IJ, Nagareddy PR, Murphy AJ. Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J Clin Invest. 2017 Jun 01; 127(6):2133-2147. PMID: 28504650; PMCID: PMC5451242.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    50. Willecke F, Scerbo D, Nagareddy P, Obunike JC, Barrett TJ, Abdillahi ML, Trent CM, Huggins LA, Fisher EA, Drosatos K, Goldberg IJ. Lipolysis, and not hepatic lipogenesis, is the primary modulator of triglyceride levels in streptozotocin-induced diabetic mice. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):102-10. PMID: 25395613; PMCID: PMC4270817.
      Citations: 28     Fields:    Translation:AnimalsCells
    51. Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014 May 06; 19(5):821-35. PMID: 24807222; PMCID: PMC4048939.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    52. Nagareddy PR, Asfour A, Klyachkin YM, Abdel-Latif A. A novel role for bioactive lipids in stem cell mobilization during cardiac ischemia: new paradigms in thrombosis: novel mediators and biomarkers. J Thromb Thrombolysis. 2014 Jan; 37(1):24-31. PMID: 24318213; PMCID: PMC4050642.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    53. Nagareddy P, Smyth SS. Inflammation and thrombosis in cardiovascular disease. Curr Opin Hematol. 2013 Sep; 20(5):457-63. PMID: 23892572; PMCID: PMC4086917.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    54. Nagareddy PR, Murphy AJ, Stirzaker RA, Hu Y, Yu S, Miller RG, Ramkhelawon B, Distel E, Westerterp M, Huang LS, Schmidt AM, Orchard TJ, Fisher EA, Tall AR, Goldberg IJ. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab. 2013 May 07; 17(5):695-708. PMID: 23663738; PMCID: PMC3992275.
      Citations: 309     Fields:    Translation:HumansAnimalsCells
    55. Tolani S, Pagler TA, Murphy AJ, Bochem AE, Abramowicz S, Welch C, Nagareddy PR, Holleran S, Hovingh GK, Kuivenhoven JA, Tall AR. Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children. Atherosclerosis. 2013 Jul; 229(1):79-85. PMID: 23684512; PMCID: PMC3691284.
      Citations: 48     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    56. Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res. 2013 May 24; 112(11):1456-65. PMID: 23572498; PMCID: PMC3839866.
      Citations: 142     Fields:    Translation:AnimalsCells
    57. Goldberg IJ, Huang LS, Huggins LA, Yu S, Nagareddy PR, Scanlan TS, Ehrenkranz JR. Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology. 2012 Nov; 153(11):5143-9. PMID: 22948212; PMCID: PMC3473203.
      Citations: 39     Fields:    Translation:Animals
    58. Nagareddy PR, Rajput PS, Vasudevan H, McClure B, Kumar U, Macleod KM, McNeill JH. Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats. Br J Pharmacol. 2012 Feb; 165(3):705-15. PMID: 21740410; PMCID: PMC3315042.
      Citations: 19     Fields:    Translation:AnimalsCells
    59. Nagareddy PR, MacLeod KM, McNeill JH. GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats. Cardiovasc Res. 2010 Jul 01; 87(1):177-86. PMID: 20110336.
      Citations: 16     Fields:    Translation:AnimalsCells
    60. Nagareddy PR, Soliman H, Lin G, Rajput PS, Kumar U, McNeill JH, MacLeod KM. Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. Diabetes. 2009 Oct; 58(10):2355-64. PMID: 19587355; PMCID: PMC2750218.
      Citations: 18     Fields:    Translation:AnimalsCells
    61. Nagareddy PR, Chow FL, Hao L, Wang X, Nishimura T, MacLeod KM, McNeill JH, Fernandez-Patron C. Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis. Cardiovasc Res. 2009 Dec 01; 84(3):368-77. PMID: 19578070.
      Citations: 22     Fields:    Translation:AnimalsCells
    62. Nagareddy PR, McNeill JH, MacLeod KM. Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats. Eur J Pharmacol. 2009 Jun 02; 611(1-3):53-9. PMID: 19344709.
      Citations: 10     Fields:    Translation:Animals
    63. Soliman H, Craig GP, Nagareddy P, Yuen VG, Lin G, Kumar U, McNeill JH, Macleod KM. Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats. Cardiovasc Res. 2008 Jul 15; 79(2):322-30. PMID: 18411229.
      Citations: 23     Fields:    Translation:AnimalsCells
    64. Xia Z, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH. N-acetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovasc Res. 2007 Mar 01; 73(4):770-82. PMID: 17250813.
      Citations: 47     Fields:    Translation:AnimalsCells
    65. Vasudevan H, Nagareddy PR, McNeill JH. Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertension. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H3058-64. PMID: 16815981.
      Citations: 15     Fields:    Translation:Animals
    66. Xia Z, Guo Z, Nagareddy PR, Yuen V, Yeung E, McNeill JH. Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats. Eur J Pharmacol. 2006 Aug 21; 544(1-3):118-25. PMID: 16859669.
      Citations: 15     Fields:    Translation:Animals
    67. Nagareddy PR, Lakshmana M. Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats. J Pharm Pharmacol. 2006 Apr; 58(4):513-9. PMID: 16597369.
      Citations: 6     Fields:    Translation:Animals
    68. Nagareddy PR, Xia Z, MacLeod KM, McNeill JH. N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats. J Cardiovasc Pharmacol. 2006 Apr; 47(4):513-20. PMID: 16680064.
      Citations: 14     Fields:    Translation:Animals
    69. Xia Z, Nagareddy PR, Guo Z, Zhang W, McNeill JH. Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats. Free Radic Res. 2006 Feb; 40(2):175-84. PMID: 16390827.
      Citations: 7     Fields:    Translation:AnimalsCells
    70. Nagareddy PR, Xia Z, McNeill JH, MacLeod KM. Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H2144-52. PMID: 16006542.
      Citations: 56     Fields:    Translation:Animals
    71. Nagareddy PR, Vasudevan H, McNeill JH. Oral administration of sodium tungstate improves cardiac performance in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2005 May; 83(5):405-11. PMID: 15897922.
      Citations: 6     Fields:    Translation:Animals
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