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Kurt Adam Zimmerman

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Nephrology
AddressBMSB 513
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R21DK140693     (ZIMMERMAN, KURT A)Sep 1, 2024 - Aug 31, 2025
    NIH
    Constructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney Disease
    Role: Principal Investigator
    R01DK129255     (ZIMMERMAN, KURT A)Sep 15, 2022 - Jun 30, 2027
    NIH
    Targeting kidney resident macrophage niche filling to slow cystic kidney disease
    Role: Principal Investigator
    K01DK119375     (ZIMMERMAN, KURT A)May 1, 2020 - Apr 30, 2024
    NIH
    Investigating CD4 T regulatory cells during rapid cystogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jansson KP, Kuluva J, Zhang S, Swanson T, Zhang Y, Zimmerman KA, Fields TA, Wallace DP, Rowe PS, Stubbs JR. Osteopontin deletion attenuates cyst growth but exacerbates fibrosis in mice with cystic kidney disease. Physiol Rep. 2024 Sep; 12(17):e70038. PMID: 39238069; PMCID: PMC11377176.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Hill K, Mullen GP, Nagareddy P, Zimmerman K, Rudolph MC. Key Questions and Gaps in Understanding Adipose Tissue Macrophages and Early-Life Metabolic Programming. Am J Physiol Endocrinol Metab. 2024 Aug 22. PMID: 39171752.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Xu X, Lin Y, Yin L, Serpa PDS, Conacher B, Pacholac C, Carvallo F, Hrubec T, Farris S, Zimmerman K, Wang X, Xie H. Spatial Transcriptomics and Single-Nucleus Multi-omics Analysis Revealing the Impact of High Maternal Folic Acid Supplementation on Offspring Brain Development. bioRxiv. 2024 Jul 16. PMID: 39071367; PMCID: PMC11275885.
      Citations:    
    4. Subramanian A, Vernon KA, Zhou Y, Marshall JL, Alimova M, Arevalo C, Zhang F, Slyper M, Waldman J, Montesinos MS, Dionne D, Nguyen LT, Cuoco MS, Dubinsky D, Purnell J, Keller K, Sturner SH, Grinkevich E, Ghoshal A, Kotek A, Trivioli G, Richoz N, Humphrey MB, Darby IG, Miller SJ, Xu Y, Weins A, Chloe-Villani A, Chang SL, Kretzler M, Rosenblatt-Rosen O, Shaw JL, Zimmerman KA, Clatworthy MR, Regev A, Greka A. Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury. Cell Rep. 2024 Jun 25; 43(6):114253. PMID: 38781074; PMCID: PMC11249042.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Patel MM, Gerakopoulos V, Petsouki E, Zimmerman KA, Tsiokas L. Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD. bioRxiv. 2024 Mar 02. PMID: 38464230; PMCID: PMC10925305.
      Citations:    
    6. Maryam B, Smith ME, Miller SJ, Natarajan H, Zimmerman KA. Macrophage Ontogeny, Phenotype, and Function in Ischemia Reperfusion Induced Injury and Repair. Kidney360. 2024 Feb 01. PMID: 38297436.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Miller SJ, Yashchenko A, Zimmerman KA. Isolation and Flow Cytometry Analysis of Macrophages from the Kidney. Methods Mol Biol. 2024; 2713:171-181. PMID: 37639123.
      Citations:    Fields:    Translation:AnimalsCells
    8. Kleczko EK, Nguyen DT, Marsh KH, Bauer CD, Li AS, Monaghan MT, Berger MD, Furgeson SB, Gitomer BY, Chonchol MB, Clambey ET, Zimmerman KA, Nemenoff RA, Hopp K. Immune checkpoint activity regulates polycystic kidney disease progression. JCI Insight. 2023 06 22; 8(12). PMID: 37345660; PMCID: PMC10371237.
      Citations:    Fields:    Translation:HumansAnimals
    9. Yashchenko A, Bland SJ, Song CJ, Ahmed UKB, Sharp R, Darby IG, Cordova AM, Smith ME, Lever JM, Li Z, Aloria EJ, Khan S, Maryam B, Liu S, Crowley MR, Jones KL, Zenewicz LA, George JF, Mrug M, Crossman DK, Hopp K, Stavrakis S, Humphrey MB, Ginhoux F, Zimmerman KA. Cx3cr1 controls kidney resident macrophage heterogeneity. Front Immunol. 2023; 14:1082078. PMID: 37256130; PMCID: PMC10225589.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Zimmerman KA, Song CJ, Aloria EJG, Li Z, Zhou J, Bland SJ, Yashchenko A, Crossman DK, Mrug M, Yoder BK. Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease. Lab Invest. 2021 10; 101(10):1382-1393. PMID: 36775437.
      Citations:    Fields:    Translation:AnimalsCells
    11. Li Z, Zimmerman KA, Cherakara S, Chumley PH, Collawn JF, Wang J, Haycraft CJ, Song CJ, Chacana T, Andersen RS, Croyle MJ, Aloria EJ, Hombal RP, Thomas IN, Chweih H, Simanyi KL, George JF, Parant JM, Mrug M, Yoder BK. A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models. Dis Model Mech. 2023 01 01; 16(1). PMID: 36457161; PMCID: PMC9884121.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Song CJ, Li Z, Ahmed UKB, Bland SJ, Yashchenko A, Liu S, Aloria EJ, Lever JM, Gonzalez NM, Bickel MA, Giles CB, Georgescu C, Wren JD, Lang ML, Benveniste EN, Harrington LE, Tsiokas L, George JF, Jones KL, Crossman DK, Agarwal A, Mrug M, Yoder BK, Hopp K, Zimmerman KA. A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice. J Am Soc Nephrol. 2022 04; 33(4):747-768. PMID: 35110364.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Zimmerman KA, Yang Z, Lever JM, Li Z, Croyle MJ, Agarwal A, Yoder BK, George JF. Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes. Am J Physiol Renal Physiol. 2021 08 01; 321(2):F162-F169. PMID: 34180717.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Aloria EJG, Song CJ, Li Z, Croyle MJ, Mrug M, Zimmerman KA, Yoder BK. Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice. Kidney360. 2021 06 24; 2(6):989-995. PMID: 34396149.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Zimmerman KA, Song CJ, Aloria EJG, Li Z, Zhou J, Bland SJ, Yashchenko A, Crossman DK, Mrug M, Yoder BK. Early infiltrating macrophage subtype correlates with late-stage phenotypic outcome in a mouse model of hepatorenal fibrocystic disease. Lab Invest. 2021 10; 101(10):1382-1393. PMID: 34158590.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Li Z, Zimmerman KA, Yoder BK. Resident Macrophages in Cystic Kidney Disease. Kidney360. 2021 01 28; 2(1):167-175. PMID: 33623927.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Zimmerman KA, Hopp K, Mrug M. Role of chemokines, innate and adaptive immunity. Cell Signal. 2020 09; 73:109647. PMID: 32325183.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    18. Zimmerman KA, Huang J, He L, Revell DZ, Li Z, Hsu JS, Fitzgibbon WR, Hazard ES, Hardiman G, Mrug M, Bell PD, Yoder BK, Saigusa T. Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease. Kidney360. 2020 Mar; 1(3):179-190. PMID: 33490963.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Larson-Casey JL, Vaid M, Gu L, He C, Cai GQ, Ding Q, Davis D, Berryhill TF, Wilson LS, Barnes S, Neighbors JD, Hohl RJ, Zimmerman KA, Yoder BK, Longhini ALF, Hanumanthu VS, Surolia R, Antony VB, Carter AB. Increased flux through the mevalonate pathway mediates fibrotic repair without injury. J Clin Invest. 2019 11 01; 129(11):4962-4978. PMID: 31609245.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    20. Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK. Tissue-Resident Macrophages Promote Renal Cystic Disease. J Am Soc Nephrol. 2019 10; 30(10):1841-1856. PMID: 31337691.
      Citations: 29     Fields:    Translation:AnimalsCells
    21. Zimmerman KA, Bentley MR, Lever JM, Li Z, Crossman DK, Song CJ, Liu S, Crowley MR, George JF, Mrug M, Yoder BK. Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species. J Am Soc Nephrol. 2019 05; 30(5):767-781. PMID: 30948627.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    22. Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF. Resident macrophages reprogram toward a developmental state after acute kidney injury. JCI Insight. 2019 Jan 24; 4(2). PMID: 30674729.
      Citations: 52     Fields:    
    23. Zimmerman KA, Gonzalez NM, Chumley P, Chacana T, Harrington LE, Yoder BK, Mrug M. Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease. Physiol Rep. 2019 01; 7(1):e13951. PMID: 30632307.
      Citations: 13     Fields:    Translation:HumansCells
    24. Zimmerman KA, Song CJ, Gonzalez-Mize N, Li Z, Yoder BK. Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver. Am J Physiol Gastrointest Liver Physiol. 2018 06 01; 314(6):G677-G689. PMID: 29543508.
      Citations: 14     Fields:    Translation:AnimalsCells
    25. Owusu BY, Zimmerman KA, Murphy-Ullrich JE. The role of the endoplasmic reticulum protein calreticulin in mediating TGF-ß-stimulated extracellular matrix production in fibrotic disease. J Cell Commun Signal. 2018 Mar; 12(1):289-299. PMID: 29080087.
      Citations: 15     
    26. Song CJ, Zimmerman KA, Henke SJ, Yoder BK. Inflammation and Fibrosis in Polycystic Kidney Disease. Results Probl Cell Differ. 2017; 60:323-344. PMID: 28409351.
      Citations: 41     Fields:    Translation:HumansAnimals
    27. Zimmerman KA, Xing D, Pallero MA, Lu A, Ikawa M, Black L, Hoyt KL, Kabarowski JH, Michalak M, Murphy-Ullrich JE. Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation. J Vasc Res. 2015; 52(5):306-20. PMID: 26910059.
      Citations: 11     Fields:    Translation:AnimalsCells
    28. Zimmerman K, Yoder BK. SnapShot: Sensing and Signaling by Cilia. Cell. 2015 Apr 23; 161(3):692-692.e1. PMID: 25910215.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    29. Zimmerman KA, Graham LV, Pallero MA, Murphy-Ullrich JE. Calreticulin regulates transforming growth factor-ß-stimulated extracellular matrix production. J Biol Chem. 2013 May 17; 288(20):14584-14598. PMID: 23564462.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    30. Parks BW, Black LL, Zimmerman KA, Metz AE, Steele C, Murphy-Ullrich JE, Kabarowski JH. CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury. J Lipid Res. 2013 Apr; 54(4):1114-23. PMID: 23393303.
      Citations: 27     Fields:    Translation:Animals
    31. Mustafa A, Holladay S, Witonsky S, Zimmerman K, Manari A, Countermarsh S, Karpuzoglu E, Gogal R. Prenatal TCDD causes persistent modulation of the postnatal immune response, and exacerbates inflammatory disease, in 36-week-old lupus-like autoimmune SNF1 mice. Birth Defects Res B Dev Reprod Toxicol. 2011 Feb; 92(1):82-94. PMID: 21312323.
      Citations: 8     Fields:    Translation:AnimalsCells
    32. Battaglia CL, Gogal RM, Zimmerman K, Misra HP. Malathion, lindane, and piperonyl butoxide, individually or in combined mixtures, induce immunotoxicity via apoptosis in murine splenocytes in vitro. Int J Toxicol. 2010 Mar-Apr; 29(2):209-20. PMID: 20075186.
      Citations: 2     Fields:    Translation:AnimalsCells
    33. Mustafa A, Holladay SD, Witonsky S, Zimmerman K, Reilly CM, Sponenberg DP, Weinstein DA, Karpuzoglu E, Gogal RM. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts B-cell lymphopoiesis and exacerbates autoimmune disease in 24-week-old SNF1 mice. Toxicol Sci. 2009 Nov; 112(1):133-43. PMID: 19666959; PMCID: PMC3304085.
      Citations: 6     Fields:    Translation:AnimalsCells
    34. Maddon PJ, Molineaux SM, Maddon DE, Zimmerman KA, Godfrey M, Alt FW, Chess L, Axel R. Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9155-9. PMID: 3501122; PMCID: PMC299711.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
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