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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 2014 Jul 15; 22(14):3753-72.
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PubMed
subject areas
Aniline Compounds
Aniline Compounds
Animals
Animals
Antineoplastic Agents
Antineoplastic Agents
Apoptosis
Apoptosis
Cell Line, Tumor
Cell Line, Tumor
Cell Proliferation
Cell Proliferation
Dose-Response Relationship, Drug
Dose-Response Relationship, Drug
Drug Discovery
Drug Discovery
Drug Screening Assays, Antitumor
Drug Screening Assays, Antitumor
Female
Female
HeLa Cells
HeLa Cells
Humans
Humans
Mice
Mice
Mice, Inbred BALB C
Mice, Inbred BALB C
Mice, Nude
Mice, Nude
Microtubules
Microtubules
Neoplasms, Experimental
Neoplasms, Experimental
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Pyrimidines
Pyrimidines
Receptor Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Solubility
Solubility
Structure-Activity Relationship
Structure-Activity Relationship
Water
Water
authors with profiles
Lora Celess Bailey-Downs
Michael Ihnat