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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade.
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med. 2019 01; 25(1):141-151.
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PubMed
subject areas
Adult
Adult
Animals
Animals
Body Weight
Body Weight
Cell Line, Tumor
Cell Line, Tumor
Cell Proliferation
Cell Proliferation
Diet
Diet
Disease Progression
Disease Progression
Female
Female
Humans
Humans
Immunotherapy
Immunotherapy
Leptin
Leptin
Male
Male
Mice, Inbred C57BL
Mice, Inbred C57BL
Mice, Obese
Mice, Obese
Middle Aged
Middle Aged
Neoplasms
Neoplasms
Obesity
Obesity
Programmed Cell Death 1 Receptor
Programmed Cell Death 1 Receptor
Signal Transduction
Signal Transduction
Species Specificity
Species Specificity
T-Lymphocytes
T-Lymphocytes
Tumor Burden
Tumor Burden
authors with profiles
Raid Aljumaily
Sami Ibrahimi
Sara Vesely