Inhibitor of Apoptosis Proteins
"Inhibitor of Apoptosis Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
| Descriptor ID |
D051034
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| MeSH Number(s) |
D08.811.464.938.750.210 D12.644.360.075.437 D12.776.476.075.437
|
| Concept/Terms |
Inhibitor of Apoptosis Proteins- Inhibitor of Apoptosis Proteins
- Apoptosis Proteins Inhibitor
- Inhibitor-Of-Apoptosis Protein
- Inhibitor Of Apoptosis Protein
- Baculoviral Inhibitor Of Apoptosis Repeat Proteins
- IAP Repeat Containing Proteins
- IAP Protein (Apoptosis)
Baculoviral IAP Repeat-Containing 2 Protein- Baculoviral IAP Repeat-Containing 2 Protein
- Baculoviral IAP Repeat Containing 2 Protein
- Cellular Inhibitor of Apoptosis 1 Protein
- IAP2 Protein
- c-IAP1 Protein
- cIAP1 Protein
- Inhibitor of Apoptosis 2 Protein
- BIRC2 Protein
- Baculoviral IAP Repeat Containing Protein 2
|
Below are MeSH descriptors whose meaning is more general than "Inhibitor of Apoptosis Proteins".
Below are MeSH descriptors whose meaning is more specific than "Inhibitor of Apoptosis Proteins".
This graph shows the total number of publications written about "Inhibitor of Apoptosis Proteins" by people in this website by year, and whether "Inhibitor of Apoptosis Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Inhibitor of Apoptosis Proteins" by people in Profiles.
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SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res. 2021 06 01; 195(6):549-560.
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Evaluating the expression level of Survivin gene in different groups of B-cell acute lymphoblastic leukemia patients of Iran. Mol Biol Rep. 2019 Jun; 46(3):2679-2684.
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Enhanced apoptosis, survivin down-regulation and assisted immunochemotherapy by curcumin loaded amphiphilic mixed micelles for subjugating endometrial cancer. Nanomedicine. 2017 Aug; 13(6):1953-1963.
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Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer. Cancer. 2016 Feb 15; 122(4):588-597.
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High Sensitivity RT-qPCR Assay of Nonlabeled siRNA in Small Blood Volume for Pharmacokinetic Studies: Application to Survivin siRNA. AAPS J. 2015 Nov; 17(6):1475-82.
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Paclitaxel tumor priming promotes delivery and transfection of intravenous lipid-siRNA in pancreatic tumors. J Control Release. 2015 Oct 28; 216:103-10.
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Intravenous siRNA Silencing of Survivin Enhances Activity of Mitomycin C in Human Bladder RT4 Xenografts. J Urol. 2015 Jul; 194(1):230-7.
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Tumor priming enhances siRNA delivery and transfection in intraperitoneal tumors. J Control Release. 2014 Mar 28; 178:79-85.
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Diagnostic role of survivin in urinary bladder cancer. Asian Pac J Cancer Prev. 2013; 14(1):81-5.
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Combination therapy for hepatocellular carcinoma: additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenib. J Hepatol. 2012 Jun; 56(6):1343-50.