G-Protein-Coupled Receptor Kinase 3
"G-Protein-Coupled Receptor Kinase 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response.
| Descriptor ID |
D054770
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| MeSH Number(s) |
D08.811.913.696.620.682.700.364.049.300 D12.644.360.293.249.300 D12.776.476.293.249.300
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinase 3".
Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinase 3".
This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinase 3" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinase 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
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Below are the most recent publications written about "G-Protein-Coupled Receptor Kinase 3" by people in Profiles.
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Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1298-303.
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The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16.
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Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells. J Pharmacol Exp Ther. 2007 Apr; 321(1):51-9.
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Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor. J Pharmacol Exp Ther. 2006 Jun; 317(3):1027-35.
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Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):794-802.
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Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. Br J Pharmacol. 2003 Mar; 138(5):921-31.
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Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure. Neuropharmacology. 2002 Nov; 43(6):979-90.
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Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9.