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Yun Zheng Le

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
AddressBSEB 302G
941 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-1087
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    Collapse Research 
    Collapse research activities and funding
    R01EY026970     (LE, YUN ZHENG)Sep 1, 2017 - May 31, 2022
    NIH
    Müller glia in disease and stress
    Role: Principal Investigator
    R01EY020900     (LE, YUN ZHENG)Sep 1, 2010 - Aug 31, 2015
    NIH
    Study of the RPE barrier
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hu J, Zhu M, Li D, Wu Q, Le YZ. Critical Role of VEGF as a Direct Regulator of Photoreceptor Function. Adv Exp Med Biol. 2023; 1415:487-491. PMID: 37440076.
      Citations:    Fields:    Translation:AnimalsCells
    2. Jiang Y, Duan LJ, Pi J, Le YZ, Fong GH. Dependence of Retinal Pigment Epithelium Integrity on the NRF2-Heme Oxygenase-1 Axis. Invest Ophthalmol Vis Sci. 2022 08 02; 63(9):30. PMID: 36036912; PMCID: PMC9434985.
      Citations:    Fields:    Translation:Animals
    3. Hu J, Zhu M, Li D, Wu Q, Le YZ. VEGF as a Direct Functional Regulator of Photoreceptors and Contributing Factor to Diabetes-Induced Alteration of Photoreceptor Function. Biomolecules. 2021 07 05; 11(7). PMID: 34356612.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Le YZ, Xu B, Chucair-Elliott AJ, Zhang H, Zhu M. VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes. Biomolecules. 2021 05 10; 11(5). PMID: 34068807.
      Citations: 11     Fields:    Translation:AnimalsCells
    5. Ma H, Yang F, Butler MR, Rapp J, Le YZ, Ding XQ. Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency. eNeuro. 2019 May/Jun; 6(3). PMID: 31182474.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Yang J, Chen C, McLaughlin T, Wang Y, Le YZ, Wang JJ, Zhang SX. Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes. Diabetologia. 2019 03; 62(3):531-543. PMID: 30612139.
      Citations: 15     Fields:    Translation:AnimalsCells
    7. Qiu F, Zhu M, Le YZ. Noninvasive Diagnosis of Regional Alteration of Retinal Morphology and Structure with Optical Coherence Tomography in Rodents. Adv Exp Med Biol. 2019; 1185:151-155. PMID: 31884604.
      Citations: 3     Fields:    Translation:Animals
    8. Xu B, Zhang H, Zhu M, Le YZ. Critical Role of Trophic Factors in Protecting Müller Glia: Implications to Neuroprotection in Age-Related Macular Degeneration, Diabetic Retinopathy, and Anti-VEGF Therapies. Adv Exp Med Biol. 2019; 1185:469-473. PMID: 31884656.
      Citations: 5     Fields:    Translation:HumansCells
    9. Royer DJ, Elliott MH, Le YZ, Carr DJJ. Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522. PMID: 29625473.
      Citations: 14     Fields:    Translation:AnimalsCells
    10. Fu S, Dong S, Zhu M, Le YZ. VEGF as a Trophic Factor for Müller Glia in Hypoxic Retinal Diseases. Adv Exp Med Biol. 2018; 1074:473-478. PMID: 29721978.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Hu J, Li T, Du X, Wu Q, Le YZ. G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. Vision Res. 2017 10; 139:59-64. PMID: 28539261.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Le YZ. VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases. Vision Res. 2017 10; 139:108-114. PMID: 28601428.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    13. Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ. Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2017 07 07; 292(27):11189-11205. PMID: 28495882.
      Citations: 20     Fields:    Translation:AnimalsCells
    14. Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, Marmorstein LY. Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7. Mol Vis. 2017; 23:228-241. PMID: 28465655.
      Citations: 36     Fields:    Translation:Animals
    15. Le YZ, Zhu M, Anderson RE. Cre Recombinase: You Can't Live with It, and You Can't Live Without It. Adv Exp Med Biol. 2016; 854:725-30. PMID: 26427481.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27; 290(48):29035-44. PMID: 26468292.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    17. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 06; 290(45):27239-27247. PMID: 26391396.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Fu S, Dong S, Zhu M, Sherry DM, Wang C, You Z, Haigh JJ, Le YZ. Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes. Diabetes. 2015 Oct; 64(10):3554-63. PMID: 26068541.
      Citations: 53     Fields:    Translation:AnimalsCells
    19. Wang JJ, Zhu M, Le YZ. Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy. World J Diabetes. 2015 Jun 10; 6(5):726-33. PMID: 26069721.
      Citations: 28     
    20. Ramamurthy V, Jolicoeur C, Koutroumbas D, Mühlhans J, Le YZ, Hauswirth WW, Giessl A, Cayouette M. Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia. J Neurosci. 2014 Oct 15; 34(42):13976-87. PMID: 25319694.
      Citations: 11     Fields:    Translation:AnimalsCells
    21. Zhou KK, Benyajati S, Le Y, Cheng R, Zhang W, Ma JX. Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization. PLoS One. 2014; 9(10):e108454. PMID: 25271989.
      Citations: 17     Fields:    Translation:AnimalsCells
    22. Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, Le YZ, Lewin AS. Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest Ophthalmol Vis Sci. 2014 Jul 01; 55(7):4613-27. PMID: 24985474.
      Citations: 65     Fields:    Translation:AnimalsCells
    23. Fu S, Zhu M, Wang C, Le YZ. Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium. Mol Vis. 2014; 20:480-7. PMID: 24744608.
      Citations: 5     Fields:    Translation:Animals
    24. Dong S, Liu Y, Zhu M, Xu X, Le YZ. Simplified system to investigate alteration of retinal neurons in diabetes. Adv Exp Med Biol. 2014; 801:139-43. PMID: 24664691.
      Citations: 4     Fields:    Translation:AnimalsCells
    25. Fu S, Zhu M, Ash JD, Wang Y, Le YZ. Investigating the role of retinal Müller cells with approaches in genetics and cell biology. Adv Exp Med Biol. 2014; 801:401-5. PMID: 24664724.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Luo L, Uehara H, Zhang X, Das SK, Olsen T, Holt D, Simonis JM, Jackman K, Singh N, Miya TR, Huang W, Ahmed F, Bastos-Carvalho A, Le YZ, Mamalis C, Chiodo VA, Hauswirth WW, Baffi J, Lacal PM, Orecchia A, Ferrara N, Gao G, Young-Hee K, Fu Y, Owen L, Albuquerque R, Baehr W, Thomas K, Li DY, Chalam KV, Shibuya M, Grisanti S, Wilson DJ, Ambati J, Ambati BK. Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1. Elife. 2013 Jun 18; 2:e00324. PMID: 23795287.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    27. He C, Zhu H, Zhang W, Okon I, Wang Q, Li H, Le YZ, Xie Z. 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. Am J Pathol. 2013 Aug; 183(2):626-37. PMID: 23770348.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    28. Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A. Autophagy protects the retina from light-induced degeneration. J Biol Chem. 2013 Mar 15; 288(11):7506-7518. PMID: 23341467.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    29. Lin M, Hu Y, Chen Y, Zhou KK, Jin J, Zhu M, Le YZ, Ge J, Ma JX. Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization. Invest Ophthalmol Vis Sci. 2012 Sep 14; 53(10):6197-206. PMID: 22915031.
      Citations: 31     Fields:    Translation:AnimalsCells
    30. Zhong Y, Li J, Wang JJ, Chen C, Tran JT, Saadi A, Yu Q, Le YZ, Mandal MN, Anderson RE, Zhang SX. X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium. PLoS One. 2012; 7(6):e38616. PMID: 22715395.
      Citations: 39     Fields:    Translation:Animals
    31. Siegert S, Cabuy E, Scherf BG, Kohler H, Panda S, Le YZ, Fehling HJ, Gaidatzis D, Stadler MB, Roska B. Transcriptional code and disease map for adult retinal cell types. Nat Neurosci. 2012 Jan 22; 15(3):487-95, S1-2. PMID: 22267162.
      Citations: 155     Fields:    Translation:AnimalsCells
    32. Zhu M, Bai Y, Zheng L, Le YZ. Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development. Adv Exp Med Biol. 2012; 723:299-304. PMID: 22183346.
      Citations: 1     Fields:    Translation:Animals
    33. Xu HZ, Song Z, Fu S, Zhu M, Le YZ. RPE barrier breakdown in diabetic retinopathy: seeing is believing. J Ocul Biol Dis Infor. 2011 Jun; 4(1-2):83-92. PMID: 23275801.
      Citations: 37     
    34. Xu H, Liu J, Xiong S, Le YZ, Xia X. Suppression of retinal neovascularization by lentivirus-mediated netrin-1 small hairpin RNA. Ophthalmic Res. 2012; 47(3):163-9. PMID: 22122983.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV. Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6355-62. PMID: 21730346.
      Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    36. Lange C, Heynen SR, Tanimoto N, Thiersch M, Le YZ, Meneau I, Seeliger MW, Samardzija M, Caprara C, Grimm C. Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5872-80. PMID: 21447692.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Kusari J, Padillo E, Zhou SX, Bai Y, Wang J, Song Z, Zhu M, Le YZ, Gil DW. Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats. Invest Ophthalmol Vis Sci. 2011 Jul 20; 52(8):5424-31. PMID: 21482645.
      Citations: 15     Fields:    Translation:HumansAnimals
    38. Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV. Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3775-83. PMID: 21398281.
      Citations: 35     Fields:    Translation:AnimalsCells
    39. Xu HZ, Le YZ. Significance of outer blood-retina barrier breakdown in diabetes and ischemia. Invest Ophthalmol Vis Sci. 2011 Apr 05; 52(5):2160-4. PMID: 21178141.
      Citations: 87     Fields:    Translation:AnimalsCells
    40. Keady BT, Le YZ, Pazour GJ. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell. 2011 Apr; 22(7):921-30. PMID: 21307337.
      Citations: 81     Fields:    Translation:AnimalsCells
    41. Le YZ. Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations. J Ophthalmol. 2011; 2011:806783. PMID: 21253511.
      Citations: 9     
    42. Wang J, Xu X, Elliott MH, Zhu M, Le YZ. Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes. 2010 Sep; 59(9):2297-305. PMID: 20530741.
      Citations: 186     Fields:    Translation:AnimalsCells
    43. Le YZ, Bai Y, Zhu M, Zheng L. Temporal requirement of RPE-derived VEGF in the development of choroidal vasculature. J Neurochem. 2010 Mar; 112(6):1584-92. PMID: 20067573.
      Citations: 31     Fields:    Translation:AnimalsCells
    44. Zhu M, Zheng L, Ueki Y, Ash JD, Le YZ. Unexpected transcriptional activity of the human VMD2 promoter in retinal development. Adv Exp Med Biol. 2010; 664:211-6. PMID: 20238019.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    45. Le YZ. Computer-assisted semi-quantitative analysis of mouse choroidal density. Adv Exp Med Biol. 2010; 664:349-53. PMID: 20238035.
      Citations: 1     Fields:    Translation:Animals
    46. Ueki Y, Chollangi S, Le YZ, Ash JD. gp130 activation in Müller cells is not essential for photoreceptor protection from light damage. Adv Exp Med Biol. 2010; 664:655-61. PMID: 20238070.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Bai Y, Ma JX, Guo J, Wang J, Zhu M, Chen Y, Le YZ. Müller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol. 2009 Dec; 219(4):446-54. PMID: 19768732.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    48. Ueki Y, Le YZ, Chollangi S, Muller W, Ash JD. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21389-94. PMID: 19948961.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    49. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303.
      Citations: 23     Fields:    Translation:HumansAnimals
    50. Thiersch M, Lange C, Joly S, Heynen S, Le YZ, Samardzija M, Grimm C. Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia-inducible factor-1 alpha expression in photoreceptors. Eur J Neurosci. 2009 Jun; 29(12):2291-302. PMID: 19508692.
      Citations: 15     Fields:    Translation:AnimalsCells
    51. Haruta M, Bush RA, Kjellstrom S, Vijayasarathy C, Zeng Y, Le YZ, Sieving PA. Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9397-402. PMID: 19470639.
      Citations: 34     Fields:    Translation:AnimalsCells
    52. Ueki Y, Ash JD, Zhu M, Zheng L, Le YZ. Expression of Cre recombinase in retinal Müller cells. Vision Res. 2009 Mar; 49(6):615-21. PMID: 19948109.
      Citations: 20     Fields:    Translation:AnimalsCells
    53. Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem. 2008 Jul 11; 283(28):19781-92. PMID: 18480052.
      Citations: 62     Fields:    Translation:AnimalsCells
    54. Le YZ, Zheng W, Rao PC, Zheng L, Anderson RE, Esumi N, Zack DJ, Zhu M. Inducible expression of cre recombinase in the retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1248-53. PMID: 18326755.
      Citations: 60     Fields:    Translation:AnimalsCells
    55. Le YZ, Zheng L, Le Y, Rucker EB, Anderson RE. Role of BCL-XL in photoreceptor survival. Adv Exp Med Biol. 2008; 613:69-74. PMID: 18188930.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    56. Zheng L, Anderson RE, Agbaga MP, Rucker EB, Le YZ. Loss of BCL-XL in rod photoreceptors: Increased susceptibility to bright light stress. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5583-9. PMID: 17122152.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    57. Le YZ, Zheng L, Zheng W, Ash JD, Agbaga MP, Zhu M, Anderson RE. Mouse opsin promoter-directed Cre recombinase expression in transgenic mice. Mol Vis. 2006 Apr 18; 12:389-98. PMID: 16636658.
      Citations: 56     Fields:    Translation:AnimalsCells
    58. Le YZ, Ash JD, Al-Ubaidi MR, Chen Y, Ma JX, Anderson RE. Conditional gene knockout system in cone photoreceptors. Adv Exp Med Biol. 2006; 572:173-8. PMID: 17249572.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    59. Le YZ, Ash JD, Al-Ubaidi MR, Chen Y, Ma JX, Anderson RE. Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice. Mol Vis. 2004 Dec 27; 10:1011-8. PMID: 15635292.
      Citations: 67     Fields:    Translation:AnimalsCells
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