Fibroblast Growth Factor 1
"Fibroblast Growth Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
| Descriptor ID |
D016220
|
| MeSH Number(s) |
D12.644.276.624.110 D12.776.467.624.110 D23.529.624.110
|
| Concept/Terms |
Fibroblast Growth Factor 1- Fibroblast Growth Factor 1
- HBGF-1
- Heparin-Binding Fibroblast Growth Factor Class I
- Heparin-Binding Growth Factor, Class I
- Heparin Binding Growth Factor, Class I
- Fibroblast Growth Factor, Acidic
- Fibroblast Growth Factor-1
- Class I Heparin-Binding Growth Factor
- FGF-1
- FGF1
- Acidic Fibroblast Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 1".
This graph shows the total number of publications written about "Fibroblast Growth Factor 1" by people in this website by year, and whether "Fibroblast Growth Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 1" by people in Profiles.
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FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer. Breast Cancer Res. 2023 08 22; 25(1):99.
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FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs. Biomolecules. 2021 07 23; 11(8).
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Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway. Cells. 2019 05 29; 8(6).
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Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c. J Biol Chem. 2017 02 10; 292(6):2495-2509.
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Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014 Nov; 20(11):1321-6.
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Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study. Ann Oncol. 2008 Nov; 19(11):1903-9.
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Expression of basic fibroblast growth factor correlates with resistance to paclitaxel in human patient tumors. Pharm Res. 2006 Jun; 23(6):1324-31.
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Nontoxic doses of suramin enhance activity of doxorubicin in prostate tumors. J Pharmacol Exp Ther. 2001 Nov; 299(2):426-33.
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Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp Eye Res. 2001 May; 72(5):591-604.
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Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8658-63.