Fibroblast Growth Factor 2
"Fibroblast Growth Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
| Descriptor ID |
D016222
|
| MeSH Number(s) |
D12.644.276.624.120 D12.776.467.624.120 D23.529.624.120
|
| Concept/Terms |
Fibroblast Growth Factor 2- Fibroblast Growth Factor 2
- Basic Fibroblast Growth Factor
- Class II Heparin-Binding Growth Factor
- Heparin-Binding Growth Factor Class II
- HBGF-2
- Prostatropin
- FGF-2
- FGF 2
- FGF2
- Fibroblast Growth Factor, Basic
- Fibroblast Growth Factor-2
- Cartilage-Derived Growth Factor
- Cartilage Derived Growth Factor
- Prostate Epithelial Cell Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 2".
This graph shows the total number of publications written about "Fibroblast Growth Factor 2" by people in this website by year, and whether "Fibroblast Growth Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 2 | 0 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 2 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 2" by people in Profiles.
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MicroRNA 221 expression in theca and granulosa cells: hormonal regulation and function. J Anim Sci. 2018 Mar 06; 96(2):641-652.
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Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. Mucosal Immunol. 2018 01; 11(1):172-185.
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Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c. J Biol Chem. 2017 02 10; 292(6):2495-2509.
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Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. Arthritis Rheumatol. 2016 12; 68(12):2975-2985.
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Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci. 2015 Aug 15; 128(16):2983-8.
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Deprivation of bFGF Promotes Spontaneous Differentiation of Human Embryonic Stem Cells into Retinal Pigment Epithelial Cells. J Stem Cells. 2015; 10(3):159-70.
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Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing. J Biol Chem. 2014 Apr 04; 289(14):9754-65.
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Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes. Cancer Chemother Pharmacol. 2012 Jul; 70(1):49-56.
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Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5872-80.
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Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats. Invest Ophthalmol Vis Sci. 2011 Jul 20; 52(8):5424-31.