"DEAD Box Protein 58" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
| Descriptor ID |
D000071457
|
| MeSH Number(s) |
D08.811.913.696.445.735.720.249.750
|
| Concept/Terms |
DEAD Box Protein 58- DEAD Box Protein 58
- DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
- Probable ATP-Dependent RNA Helicase DDX58
- Probable ATP Dependent RNA Helicase DDX58
- RIG-I-like Receptor 1
- RIG I like Receptor 1
|
Below are MeSH descriptors whose meaning is more general than "DEAD Box Protein 58".
Below are MeSH descriptors whose meaning is more specific than "DEAD Box Protein 58".
This graph shows the total number of publications written about "DEAD Box Protein 58" by people in this website by year, and whether "DEAD Box Protein 58" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "DEAD Box Protein 58" by people in Profiles.
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RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo. Mediators Inflamm. 2018; 2018:6808934.
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RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir Res. 2017 09 02; 18(1):166.
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Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses. Respir Res. 2016 09 07; 17(1):111.
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RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells. Virology. 2015 Aug; 482:181-8.
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Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L848-58.
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Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung. PLoS One. 2012; 7(11):e49856.
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Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L821-30.
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RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem. 2009 Apr 17; 284(16):10774-82.