Hypoxia-Inducible Factor 1, alpha Subunit
"Hypoxia-Inducible Factor 1, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
| Descriptor ID |
D051795
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| MeSH Number(s) |
D12.776.260.103.625.750 D12.776.930.125.625.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Hypoxia-Inducible Factor 1, alpha Subunit".
Below are MeSH descriptors whose meaning is more specific than "Hypoxia-Inducible Factor 1, alpha Subunit".
This graph shows the total number of publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in this website by year, and whether "Hypoxia-Inducible Factor 1, alpha Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 1 | 3 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2012 | 3 | 0 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 3 | 5 |
| 2020 | 2 | 1 | 3 |
| 2021 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hypoxia-Inducible Factor 1, alpha Subunit" by people in Profiles.
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The human testis-enriched HSPA2 interacts with HIF-1a in epidermal keratinocytes, yet HIF-1a stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity. Biochim Biophys Acta Mol Cell Res. 2024 Jun; 1871(5):119735.
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CopA3 treatment suppressed multidrug resistivity in HCT-116 cell line by p53-induced degradation of hypoxia-inducible factor 1a. Life Sci. 2023 Sep 15; 329:121933.
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Patients with repaired tetralogy of Fallot and the HIF1A1744C/T variant have increased imaging markers of diffuse myocardial fibrosis. Int J Cardiol. 2022 Mar 01; 350:33-35.
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Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer. Adv Drug Deliv Rev. 2021 11; 178:113918.
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Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1a-NF-?B Crosstalk In Vitro and In Vivo. Int J Mol Sci. 2020 Dec 04; 21(23).
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Squalene deters drivers of RCC disease progression beyond VHL status. Cell Biol Toxicol. 2021 08; 37(4):611-631.
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Cystathione ß-synthase regulates HIF-1a stability through persulfidation of PHD2. Sci Adv. 2020 07; 6(27).
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Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts. Cancer Lett. 2019 02 01; 442:464-474.
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Targeting Hypoxia-Inducible Factor-1a/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 02; 58(2):216-231.
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LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response. Cancer Res. 2018 04 15; 78(8):1923-1934.