Solute Carrier Organic Anion Transporter Family Member 1B3
"Solute Carrier Organic Anion Transporter Family Member 1B3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sodium-independent organic anion transporter that functions in the uptake of various drugs and endogenous compounds including ESTRADIOL; TAUROCHOLATE; LEUKOTRIENE C4; and METHOTREXATE. It also functions in clearing BILE ACIDS and organic anions from the liver. Mutations in the SLCO1B3 gene are associated with Rotor Type HYPERBILIRUBINEMIA.
| Descriptor ID |
D000074542
|
| MeSH Number(s) |
D12.776.157.530.450.074.500.781.875 D12.776.157.530.937.905 D12.776.543.585.450.074.500.875.875 D12.776.543.585.937.950
|
| Concept/Terms |
Solute Carrier Organic Anion Transporter Family Member 1B3- Solute Carrier Organic Anion Transporter Family Member 1B3
- OATP8 Protein
- Solute Carrier Family 21 Member 8 Protein
- Liver-Specific Organic Anion Transporter-2
- Liver Specific Organic Anion Transporter 2
- OATP1B3 Protein
- SLC21A8 Protein
- SLCO1B3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Solute Carrier Organic Anion Transporter Family Member 1B3".
Below are MeSH descriptors whose meaning is more specific than "Solute Carrier Organic Anion Transporter Family Member 1B3".
This graph shows the total number of publications written about "Solute Carrier Organic Anion Transporter Family Member 1B3" by people in this website by year, and whether "Solute Carrier Organic Anion Transporter Family Member 1B3" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Solute Carrier Organic Anion Transporter Family Member 1B3" by people in Profiles.
-
Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations. AAPS J. 2021 08 25; 23(5):102.
-
Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds. J Pharm Pharm Sci. 2021; 24:475-483.
-
Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interaction Potential of Vemurafenib Using R-Value and Physiologically-Based Pharmacokinetic Models. J Pharm Sci. 2021 01; 110(1):314-324.
-
Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism. Pharm Res. 2019 May 15; 36(7):101.
-
Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. J Pharm Sci. 2019 10; 108(10):3443-3456.
-
Characterization of Liver- and Cancer-type-Organic Anion Transporting Polypeptide (OATP) 1B3 Messenger RNA Expression in Normal and Cancerous Human Tissues. Drug Metab Lett. 2018; 12(1):24-32.
-
Treatment with proteasome inhibitor bortezomib decreases organic anion transporting polypeptide (OATP) 1B3-mediated transport in a substrate-dependent manner. PLoS One. 2017; 12(11):e0186924.
-
Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport. J Pharm Sci. 2017 08; 106(8):2123-2135.
-
Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation. Drug Metab Dispos. 2014 Nov; 42(11):1964-70.