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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 04 01; 27(7):1602-1607.
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PubMed
subject areas
Angiogenesis Inhibitors
Angiogenesis Inhibitors
Animals
Animals
Antineoplastic Agents
Antineoplastic Agents
Cell Line, Tumor
Cell Line, Tumor
Cisplatin
Cisplatin
Folic Acid Antagonists
Folic Acid Antagonists
Heterocyclic Compounds, 3-Ring
Heterocyclic Compounds, 3-Ring
Humans
Humans
Indoles
Indoles
Mice
Mice
Pemetrexed
Pemetrexed
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Pyrimidines
Pyrimidines
Pyrroles
Pyrroles
Receptor Protein-Tyrosine Kinases
Receptor Protein-Tyrosine Kinases
Receptor, Platelet-Derived Growth Factor beta
Receptor, Platelet-Derived Growth Factor beta
Thymidylate Synthase
Thymidylate Synthase
Vascular Endothelial Growth Factor Receptor-2
Vascular Endothelial Growth Factor Receptor-2
Xenograft Model Antitumor Assays
Xenograft Model Antitumor Assays
authors with profiles
Michael Ihnat