The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change.
The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39.
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Animals
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Animals
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Blotting, Western
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Blotting, Western
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Calcium
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Calcium
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Cell Line
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Cell Line
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Circular Dichroism
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Circular Dichroism
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Cyclic Nucleotide-Gated Cation Channels
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Cyclic Nucleotide-Gated Cation Channels
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Electrophoresis, Polyacrylamide Gel
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Electrophoresis, Polyacrylamide Gel
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Electrophysiology
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Electrophysiology
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Escherichia coli
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Escherichia coli
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Fluorescent Antibody Technique
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Fluorescent Antibody Technique
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Humans
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Humans
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Mice
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Mice
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Microscopy, Confocal
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Microscopy, Confocal
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Models, Biological
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Models, Biological
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Mutation
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Mutation
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Protein Stability
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Protein Stability
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Protein Structure, Secondary
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Protein Structure, Secondary
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Recombinant Proteins
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Recombinant Proteins
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Structure-Activity Relationship
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Structure-Activity Relationship