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Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ß-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft.
Secologanin Tryptamine Alkaloids
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Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ß-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft.
Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ß-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. 2013 Nov; 78(11):1071-86.
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PubMed
subject areas
Animals
Animals
Antineoplastic Agents
Antineoplastic Agents
Apoptosis
Apoptosis
Benzopyrans
Benzopyrans
Binding, Competitive
Binding, Competitive
Biomarkers, Tumor
Biomarkers, Tumor
Breast Neoplasms
Breast Neoplasms
Cell Cycle Checkpoints
Cell Cycle Checkpoints
Cell Proliferation
Cell Proliferation
Cyclin D1
Cyclin D1
Epidermal Growth Factor
Epidermal Growth Factor
ErbB Receptors
ErbB Receptors
Estrogen Receptor alpha
Estrogen Receptor alpha
Estrogen Receptor beta
Estrogen Receptor beta
G2 Phase Cell Cycle Checkpoints
G2 Phase Cell Cycle Checkpoints
Humans
Humans
M Phase Cell Cycle Checkpoints
M Phase Cell Cycle Checkpoints
MCF-7 Cells
MCF-7 Cells
Mice
Mice
Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3-Kinases
Piperidines
Piperidines
Promoter Regions, Genetic
Promoter Regions, Genetic
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-akt
Receptors, Estrogen
Receptors, Estrogen
Signal Transduction
Signal Transduction
Transcription Factor AP-1
Transcription Factor AP-1
Transcriptional Activation
Transcriptional Activation
Xenograft Model Antitumor Assays
Xenograft Model Antitumor Assays
authors with profiles
Vishal Chandra