Methylenetetrahydrofolate Dehydrogenase (NADP)
"Methylenetetrahydrofolate Dehydrogenase (NADP)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Descriptor ID |
D008754
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MeSH Number(s) |
D08.811.682.662.253
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methylenetetrahydrofolate Dehydrogenase (NADP)".
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Below are the most recent publications written about "Methylenetetrahydrofolate Dehydrogenase (NADP)" by people in Profiles.
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Tetrahydrofolate enzyme levels in Acetobacterium woodii and their implication in the synthesis of acetate from CO2. J Bacteriol. 1978 May; 134(2):668-70.