"Phenobarbital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
| Descriptor ID |
D010634
|
| MeSH Number(s) |
D03.383.742.698.253.650
|
| Concept/Terms |
Phenobarbital- Phenobarbital
- Phenylbarbital
- Phenylethylbarbituric Acid
- Acid, Phenylethylbarbituric
- Phenemal
- Phenobarbitone
Phenobarbital Sodium- Phenobarbital Sodium
- Sodium, Phenobarbital
- Phenobarbital, Monosodium Salt
- Monosodium Salt Phenobarbital
|
Below are MeSH descriptors whose meaning is more general than "Phenobarbital".
Below are MeSH descriptors whose meaning is more specific than "Phenobarbital".
This graph shows the total number of publications written about "Phenobarbital" by people in this website by year, and whether "Phenobarbital" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phenobarbital" by people in Profiles.
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A confusing case of confusion. Acute porphyrias. J Okla State Med Assoc. 2008 Apr; 101(4):85-6, 89-90.
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Chronic prenatal exposure to phenobarbital and long-term behavior effects on mice offspring. J Matern Fetal Neonatal Med. 2004 Jun; 15(6):351-5.
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Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis. Mol Carcinog. 1994 Jan; 9(1):2-9.
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Pharmacological effects of enantiomers of 4-amino-N-(alpha-methylbenzyl)benzamide, a chemically novel anticonvulsant. Epilepsia. 1988 Jan-Feb; 29(1):83-90.
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Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species. Biochem Pharmacol. 1987 Apr 01; 36(7):1083-90.
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Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital. Cancer Res. 1985 Dec; 45(12 Pt 1):6063-70.
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Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver. J Natl Cancer Inst. 1985 Dec; 75(6):1107-12.
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The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver. Cancer Lett. 1985 Oct; 29(1):1-14.
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p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol. Drug Metab Dispos. 1985 Sep-Oct; 13(5):548-52.
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Inhibition of p-nitroanisole O-demethylation in perfused rat liver by potassium cyanide. Arch Biochem Biophys. 1983 Aug; 225(1):313-9.