"Plicamycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
| Descriptor ID |
D008926
|
| MeSH Number(s) |
D02.455.426.559.847.562.050.650 D04.615.562.050.650 D09.408.051.059.650
|
| Concept/Terms |
Plicamycin- Plicamycin
- Mitramycin
- Aureolic Acid
- Acid, Aureolic
- Mithramycin
|
Below are MeSH descriptors whose meaning is more general than "Plicamycin".
Below are MeSH descriptors whose meaning is more specific than "Plicamycin".
This graph shows the total number of publications written about "Plicamycin" by people in this website by year, and whether "Plicamycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Plicamycin" by people in Profiles.
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Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin. Microb Cell Fact. 2020 May 24; 19(1):111.
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Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY. Microbiology (Reading). 2015 Feb; 161(Pt 2):272-284.
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Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors. Cancer Res. 2014 Feb 15; 74(4):1200-13.
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Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus. Metab Eng. 2013 Nov; 20:187-97.
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Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):387-93.