"Philadelphia Chromosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aberrant form of human CHROMOSOME 22 characterized by translocation of the distal end of chromosome 9 from 9q34, to the long arm of chromosome 22 at 22q11. It is present in the bone marrow cells of 80 to 90 per cent of patients with chronic myelocytic leukemia (LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE).
| Descriptor ID |
D010677
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| MeSH Number(s) |
A11.284.187.520.300.325.345.500 A11.284.187.520.300.505.515.500 C23.550.210.870.680 G05.360.162.520.300.325.345.700 G05.360.162.520.300.505.515.700 G05.365.590.175.870.680
|
| Concept/Terms |
Philadelphia Chromosome- Philadelphia Chromosome
- Chromosome, Philadelphia
- Ph 1 Chromosome
- 1 Chromosomes, Ph
- Chromosome, Ph 1
- Chromosomes, Ph 1
- Ph 1 Chromosomes
- Ph1 Chromosome
- Chromosome, Ph1
- Chromosomes, Ph1
- Ph1 Chromosomes
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Below are MeSH descriptors whose meaning is more general than "Philadelphia Chromosome".
- Anatomy [A]
- Cells [A11]
- Cellular Structures [A11.284]
- Chromosomes [A11.284.187]
- Chromosomes, Mammalian [A11.284.187.520]
- Chromosomes, Human [A11.284.187.520.300]
- Chromosomes, Human, 6-12 and X [A11.284.187.520.300.325]
- Chromosomes, Human, Pair 9 [A11.284.187.520.300.325.345]
- Philadelphia Chromosome [A11.284.187.520.300.325.345.500]
- Chromosomes, Human, 21-22 and Y [A11.284.187.520.300.505]
- Chromosomes, Human, Pair 22 [A11.284.187.520.300.505.515]
- Philadelphia Chromosome [A11.284.187.520.300.505.515.500]
- Diseases [C]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Chromosome Aberrations [C23.550.210]
- Translocation, Genetic [C23.550.210.870]
- Philadelphia Chromosome [C23.550.210.870.680]
- Biological Sciences [G]
- Genetic Phenomena [G05]
- Genetic Structures [G05.360]
- Chromosomes [G05.360.162]
- Chromosomes, Mammalian [G05.360.162.520]
- Chromosomes, Human [G05.360.162.520.300]
- Chromosomes, Human, 6-12 and X [G05.360.162.520.300.325]
- Chromosomes, Human, Pair 9 [G05.360.162.520.300.325.345]
- Philadelphia Chromosome [G05.360.162.520.300.325.345.700]
- Chromosomes, Human, 21-22 and Y [G05.360.162.520.300.505]
- Chromosomes, Human, Pair 22 [G05.360.162.520.300.505.515]
- Philadelphia Chromosome [G05.360.162.520.300.505.515.700]
- Genetic Variation [G05.365]
- Mutation [G05.365.590]
- Chromosome Aberrations [G05.365.590.175]
- Translocation, Genetic [G05.365.590.175.870]
- Philadelphia Chromosome [G05.365.590.175.870.680]
Below are MeSH descriptors whose meaning is more specific than "Philadelphia Chromosome".
This graph shows the total number of publications written about "Philadelphia Chromosome" by people in this website by year, and whether "Philadelphia Chromosome" was a major or minor topic of these publications.
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Below are the most recent publications written about "Philadelphia Chromosome" by people in Profiles.
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SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia. J Clin Oncol. 2022 05 10; 40(14):1574-1582.
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Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL. Blood Adv. 2021 11 23; 5(22):4691-4700.
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Acute Lymphoblastic Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 09 20; 19(9):1079-1109.
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In the Era of BCR-ABL1 Inhibitors, Are We Closing the Survival Gap Between Allogeneic Hematopoietic Cell Transplantation and Chemotherapy for Philadelphia Chromosome-Positive?Acute Lymphoblastic Leukemia in First Complete Remission? Biol Blood Marrow Transplant. 2018 04; 24(4):637-638.
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How should we treat older adults with Ph+ adult ALL and what novel approaches are being investigated? Best Pract Res Clin Haematol. 2017 09; 30(3):201-211.
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Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics. 1995 May 01; 27(1):67-82.