"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
| Descriptor ID |
D016874
|
| MeSH Number(s) |
A08.675.609.520 A11.284.430.214.190.750.640.520 A11.671.573.520
|
| Concept/Terms |
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
|
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in this website by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 0 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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Alzheimer's Disease Markers in Aged ApoE-PON1 Deficient Mice. J Alzheimers Dis. 2019; 67(4):1353-1365.
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Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain. PLoS One. 2015; 10(7):e0132637.
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How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug; 68:51-8.
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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006 Oct 04; 26(40):10129-40.
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Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Ann Neurol. 2005 Nov; 58(5):748-57.
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Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging. 2006 Oct; 27(10):1359-71.
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Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta. 2005 Jan 03; 1739(2-3):198-210.
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Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. J Mol Neurosci. 2003; 20(3):425-9.
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Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol. 2003 Apr; 105(4):381-92.
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Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):95-9.