An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

Descriptor ID	D018455
MeSH Number(s)	C15.378.100.800 C15.378.147.890 C15.378.925.800
Concept/Terms	Protein S Deficiency Protein S Deficiency Hereditary Thrombophilia Due To Protein S Deficiency Deficiency, Protein S Deficiencies, Protein S Protein S Deficiencies

Below are MeSH descriptors whose meaning is more general than "Protein S Deficiency".

Below are MeSH descriptors whose meaning is related to "Protein S Deficiency".

Below are MeSH descriptors whose meaning is more specific than "Protein S Deficiency".