Mutagenesis, Site-Directed
"Mutagenesis, Site-Directed" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
| Descriptor ID |
D016297
|
| MeSH Number(s) |
E05.393.420.601.575
|
| Concept/Terms |
Mutagenesis, Site-Directed- Mutagenesis, Site-Directed
- Mutagenesis, Site Directed
- Site-Specific Mutagenesis
- Site Specific Mutagenesis
- Mutagenesis, Site-Specific
- Mutageneses, Site-Specific
- Mutagenesis, Site Specific
- Site-Specific Mutageneses
- Site-Directed Mutagenesis
- Mutageneses, Site-Directed
- Site Directed Mutagenesis
- Site-Directed Mutageneses
Oligonucleotide-Directed Mutagenesis- Oligonucleotide-Directed Mutagenesis
- Oligonucleotide Directed Mutagenesis
- Mutagenesis, Oligonucleotide-Directed
- Mutageneses, Oligonucleotide-Directed
- Mutagenesis, Oligonucleotide Directed
- Oligonucleotide-Directed Mutageneses
|
Below are MeSH descriptors whose meaning is more general than "Mutagenesis, Site-Directed".
Below are MeSH descriptors whose meaning is more specific than "Mutagenesis, Site-Directed".
This graph shows the total number of publications written about "Mutagenesis, Site-Directed" by people in this website by year, and whether "Mutagenesis, Site-Directed" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 7 | 7 |
| 2000 | 0 | 11 | 11 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 6 | 7 |
| 2004 | 0 | 9 | 9 |
| 2005 | 0 | 6 | 6 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 4 | 4 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 4 | 4 |
| 2015 | 1 | 2 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mutagenesis, Site-Directed" by people in Profiles.
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Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator. Biochemistry. 2021 07 06; 60(26):2130-2151.
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Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. Int J Oncol. 2020 12; 57(6):1319-1332.
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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437.
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Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem. 2018 10 12; 293(41):15840-15854.
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Identification of the Ferredoxin-Binding Site of a Ferredoxin-Dependent Cyanobacterial Nitrate Reductase. Biochemistry. 2017 10 17; 56(41):5582-5592.
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Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A. Biochem Biophys Res Commun. 2016 Jan 01; 469(1):114-119.
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Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis. Arch Biochem Biophys. 2015 Oct 15; 584:98-106.
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Rapid selective sweep of pre-existing polymorphisms and slow fixation of new mutations in experimental evolution of Desulfovibrio vulgaris. ISME J. 2015 Nov; 9(11):2360-72.
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Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. ACS Chem Biol. 2014 Oct 17; 9(10):2347-58.
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Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem. 2014 Sep 26; 289(39):26743-26751.