"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.
| Descriptor ID |
D016350
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.520
|
| Concept/Terms |
Leucine Zippers- Leucine Zippers
- Leucine Zipper
- Zipper, Leucine
- Zippers, Leucine
|
Below are MeSH descriptors whose meaning is more general than "Leucine Zippers".
Below are MeSH descriptors whose meaning is more specific than "Leucine Zippers".
This graph shows the total number of publications written about "Leucine Zippers" by people in this website by year, and whether "Leucine Zippers" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leucine Zippers" by people in Profiles.
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JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway. Biochemistry. 2005 Nov 01; 44(43):14090-6.
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AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J Biol Chem. 2004 Feb 06; 279(6):4596-603.
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Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA. Scand J Immunol. 2001 Mar; 53(3):268-76.
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The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 2000 Aug; 155(4):1711-23.
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Replication and control of circular bacterial plasmids. Microbiol Mol Biol Rev. 1998 Jun; 62(2):434-64.
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Interaction of the bHLH-zip domain of c-Myc with H1-type peptides. Characterization of helicity in the H1 peptides by NMR. J Biol Chem. 1994 Jan 21; 269(3):1785-93.
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Regulation of genetic expression in shear stress-stimulated endothelial cells. Ann N Y Acad Sci. 1992 Oct 13; 665:94-104.