"Genes, erbB-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
| Descriptor ID |
D018734
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.295.305
|
| Concept/Terms |
Genes, erbB-2- Genes, erbB-2
- c-erbB-2 Genes
- c erbB 2 Genes
- c-erbB-2 Gene
- Genes, erbb2
- Gene, erbb2
- erbb2 Gene
- erbb2 Genes
- Genes, HER-2
- HER-2 Gene
- HER-2 Genes
- Genes, neu
- neu Gene
- neu Genes
- Genes, HER2
- Gene, HER2
- HER2 Gene
- HER2 Genes
- erbB-2 Genes
- erbB 2 Genes
- erbB-2 Gene
- c-erbB-2 Proto-Oncogenes
- c erbB 2 Proto Oncogenes
- c-erbB-2 Proto-Oncogene
|
Below are MeSH descriptors whose meaning is more general than "Genes, erbB-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, erbB-2".
This graph shows the total number of publications written about "Genes, erbB-2" by people in this website by year, and whether "Genes, erbB-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, erbB-2" by people in Profiles.
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Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice. J Biol Chem. 2015 Aug 14; 290(33):20159-66.
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Assessment of HER2 gene status in breast carcinomas with polysomy of chromosome 17. Cancer. 2011 Jan 01; 117(1):48-53.
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FISH for HER-2/neu in breast cancer: standardization makes the difference! Indian J Cancer. 2004 Oct-Dec; 41(4):152-8.
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Mammary tumor heterogeneity in wt-ErbB-2 transgenic mice. Comp Med. 2004 Jun; 54(3):280-7.
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HER2/neu gene amplification and protein overexpression in G3 pT2 transitional cell carcinoma of the bladder: a role for anti-HER2 therapy? Eur J Cancer. 2004 Jan; 40(1):56-63.
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Hormonal and dietary modulation of mammary carcinogenesis in mouse mammary tumor virus-c-erbB-2 transgenic mice. Cancer Res. 2003 May 15; 63(10):2425-33.
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Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. J Cell Biochem. 2002; 86(1):174-83.
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Resistance to transformation by insertionally activated c-erbB is a dominant phenotype in fibroblasts. Virology. 1995 Sep 10; 212(1):277-83.