"Peptaibols" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of peptides characterized by length of 1-2 dozen residues with a high proportion of them being non-proteinogenic, notably alpha-aminoisobutyric acid (Aib) and isovaline, and have a C-terminal amino alcohol and N terminal alkyl group. They are found in FUNGI and some are ANTI-INFECTIVE AGENTS. They form channels or pores in target organisms. The term is a contraction of peptide-Aib-alcohol.
| Descriptor ID |
D054848
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| MeSH Number(s) |
D12.644.504
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peptaibols".
Below are MeSH descriptors whose meaning is more specific than "Peptaibols".
This graph shows the total number of publications written about "Peptaibols" by people in this website by year, and whether "Peptaibols" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Peptaibols" by people in Profiles.
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Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum. J Nat Prod. 2022 06 24; 85(6):1603-1616.
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Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea. Molecules. 2021 Jun 11; 26(12).
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Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics. J Nat Prod. 2021 02 26; 84(2):503-517.
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Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E8957-E8966.