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Karen L Wozniak

TitleProf, Asst
InstitutionOklahoma State University
DepartmentMicrobiology and Molecular Genetics
Addressn/a
307 Life Sciences East
Stillwater OK 74078
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    Collapse Research 
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    R15AI183184     (WOZNIAK, KAREN LYNN)Apr 12, 2024 - Mar 31, 2027
    NIH
    Mechanisms of Antifungal Activity of Dendritic Cell Lysosomal Proteins
    Role: Principal Investigator
    R13AI150092     (WOZNIAK, KAREN LYNN)Nov 19, 2019 - Oct 31, 2020
    NIH
    2019 South Central Medical Mycology Conference
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heydarian N, Ferrell M, Nair AS, Roedl C, Peng Z, Nguyen TD, Best W, Wozniak KL, Rice CV. Low-Molecular Weight Branched Polyethylenimine Reduces Cytokine Secretion from Human Immune System Monocytes Stimulated with Bacterial and Fungal PAMPs. ChemMedChem. 2024 Aug 01; 19(15):e202400011. PMID: 38740551.
      Citations:    Fields:    Translation:HumansCells
    2. Salpadoru T, Pinks KE, Lieberman JA, Cotton K, Wozniak KL, Gerasimchuk N, Patrauchan MA. Novel antimony-based antimicrobial drug targets membranes of Gram-positive and Gram-negative bacterial pathogens. Microbiol Spectr. 2024 Jun 04; 12(6):e0423423. PMID: 38651882; PMCID: PMC11237720.
      Citations:    Fields:    Translation:HumansCells
    3. Heydarian N, Ferrell M, Nair AS, Roedl C, Peng Z, Nguyen TD, Best W, Wozniak KL, Rice CV. Neutralizing Staphylococcus aureus PAMPs that Trigger Cytokine Release from THP-1 Monocytes. ACS Omega. 2024 Mar 05; 9(9):10967-10978. PMID: 38463252; PMCID: PMC10918781.
      Citations: 1     
    4. Conn BN, Lieberman JA, Chatman P, Cotton K, Essandoh MA, Ebqa'ai M, Nelson TL, Wozniak KL. Antifungal activity of eumelanin-inspired indoylenepheyleneethynylene against Cryptococcus neoformans. Front Microbiol. 2023; 14:1339303. PMID: 38293553; PMCID: PMC10826398.
      Citations:    
    5. Alake SE, Ice J, Robinson K, Price P, Hatter B, Wozniak K, Lin D, Chowanadisai W, Smith BJ, Lucas EA. Reduced estrogen signaling contributes to bone loss and cardiac dysfunction in interleukin-10 knockout mice. Physiol Rep. 2024 Jan; 12(1):e15914. PMID: 38217044; PMCID: PMC10787104.
      Citations: 1     Fields:    Translation:Animals
    6. Goughenour KD, Nair AS, Xu J, Olszewski MA, Wozniak KL. Dendritic Cells: Multifunctional Roles in Host Defenses to Cryptococcus Infections. J Fungi (Basel). 2023 Oct 26; 9(11). PMID: 37998856; PMCID: PMC10672120.
      Citations: 3     
    7. Conn BN, Wozniak KL. Innate Pulmonary Phagocytes and Their Interactions with Pathogenic Cryptococcus Species. J Fungi (Basel). 2023 May 27; 9(6). PMID: 37367553; PMCID: PMC10299524.
      Citations: 2     
    8. Alake SE, Lightfoot S, Wozniak K, Lin D, Chowanadisai W, Smith BJ, Lucas EA. Wheat Germ Supplementation Reduces Inflammation and Gut Epithelial Barrier Dysfunction in Female Interleukin-10 Knockout Mice Fed a Pro-Atherogenic Diet. J Nutr. 2023 03; 153(3):870-879. PMID: 36813578.
      Citations: 3     Fields:    Translation:Animals
    9. Nelson BN, Daugherty CS, Sharp RR, Booth JL, Patel VI, Metcalf JP, Jones KL, Wozniak KL. Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation. Front Immunol. 2022; 13:1054477. PMID: 36466930; PMCID: PMC9709479.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    10. Gerasimchuk N, Pinks K, Salpadoru T, Cotton K, Michka O, Patrauchan MA, Wozniak KL. Non-Antibiotic Antimony-Based Antimicrobials. Molecules. 2022 Oct 23; 27(21). PMID: 36363997; PMCID: PMC9654735.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Hawkins AN, Determann BF, Nelson BN, Wozniak KL. Transcriptional Changes in Pulmonary Phagocyte Subsets Dictate the Outcome Following Interaction With The Fungal Pathogen Cryptococcus neoformans. Front Immunol. 2021; 12:722500. PMID: 34650554.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Nelson BN, Beakley SG, Posey S, Conn B, Maritz E, Seshu J, Wozniak KL. Antifungal activity of dendritic cell lysosomal proteins against Cryptococcus neoformans. Sci Rep. 2021 06 30; 11(1):13619. PMID: 34193926.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Chen Y, Vargas SM, Smith TC, Karna SLR, MacMackin Ingle T, Wozniak KL, Wormley FL, Seshu J. Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease. PLoS Pathog. 2021 04; 17(4):e1009535. PMID: 33882111.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Nelson BN, Hawkins AN, Wozniak KL. Pulmonary Macrophage and Dendritic Cell Responses to Cryptococcus neoformans. Front Cell Infect Microbiol. 2020; 10:37. PMID: 32117810.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    15. Hole CR, Wager CML, Castro-Lopez N, Campuzano A, Cai H, Wozniak KL, Wang Y, Wormley FL. Induction of memory-like dendritic cell responses in vivo. Nat Commun. 2019 07 04; 10(1):2955. PMID: 31273203.
      Citations: 68     Fields:    Translation:AnimalsCellsPHPublic Health
    16. Leopold Wager CM, Hole CR, Campuzano A, Castro-Lopez N, Cai H, Caballero Van Dyke MC, Wozniak KL, Wang Y, Wormley FL. IFN-? immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans. PLoS Pathog. 2018 10; 14(10):e1007358. PMID: 30304063.
      Citations: 40     Fields:    Translation:AnimalsCells
    17. Wozniak KL. Interactions of Cryptococcus with Dendritic Cells. J Fungi (Basel). 2018 Mar 15; 4(1). PMID: 29543719.
      Citations: 11     
    18. Van Dyke MCC, Chaturvedi AK, Hardison SE, Leopold Wager CM, Castro-Lopez N, Hole CR, Wozniak KL, Wormley FL. Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes. Front Immunol. 2017; 8:1359. PMID: 29163469.
      Citations: 12     Fields:    
    19. Campuzano A, Castro-Lopez N, Wozniak KL, Leopold Wager CM, Wormley FL. Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection. PLoS One. 2017; 12(1):e0169347. PMID: 28107361.
      Citations: 24     Fields:    Translation:Animals
    20. Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL. Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species. Infect Immun. 2016 09; 84(9):2493-504. PMID: 27324480.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    21. Leopold Wager CM, Hole CR, Wozniak KL, Wormley FL. Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome. Front Microbiol. 2016; 7:105. PMID: 26903984.
      Citations: 53     
    22. Hung CY, Wozniak KL, Cole GT. Flow Cytometric Analysis of Protective T-Cell Response Against Pulmonary Coccidioides Infection. Methods Mol Biol. 2016; 1403:551-66. PMID: 27076153.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Zhai B, Wozniak KL, Masso-Silva J, Upadhyay S, Hole C, Rivera A, Wormley FL, Lin X. Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants. mBio. 2015 Oct 06; 6(5):e01433-15. PMID: 26443458.
      Citations: 41     Fields:    Translation:Animals
    24. Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Mueller M, Wormley FL. STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans. Infect Immun. 2015 Dec; 83(12):4513-27. PMID: 26351277.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    25. Wozniak KL, Olszewski MA, Wormley FL. Molecules at the interface of Cryptococcus and the host that determine disease susceptibility. Fungal Genet Biol. 2015 May; 78:87-92. PMID: 25445308.
      Citations: 11     Fields:    Translation:Animals
    26. Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormley FL. STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice. J Immunol. 2014 Oct 15; 193(8):4060-71. PMID: 25200956.
      Citations: 54     Fields:    Translation:AnimalsCells
    27. Chaturvedi AK, Hameed RS, Wozniak KL, Hole CR, Leopold Wager CM, Weintraub ST, Lopez-Ribot JL, Wormley FL. Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice. PLoS One. 2014; 9(8):e104316. PMID: 25119981.
      Citations: 25     Fields:    Translation:Animals
    28. Wozniak KL, Hole CR, Yano J, Fidel PL, Wormley FL. Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection. Microbiology (Reading). 2014 Jul; 160(Pt 7):1440-1452. PMID: 24760968.
      Citations: 18     Fields:    Translation:HumansAnimals
    29. Wozniak KL, Kolls JK, Wormley FL. Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by ?d T cells. BMC Immunol. 2012 Dec 07; 13:65. PMID: 23216912.
      Citations: 52     Fields:    Translation:AnimalsCells
    30. Hole CR, Bui H, Wormley FL, Wozniak KL. Mechanisms of dendritic cell lysosomal killing of Cryptococcus. Sci Rep. 2012; 2:739. PMID: 23074646.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    31. Yano J, Kolls JK, Happel KI, Wormley F, Wozniak KL, Fidel PL. The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway. PLoS One. 2012; 7(9):e46311. PMID: 23050010.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    32. Hardison SE, Herrera G, Young ML, Hole CR, Wozniak KL, Wormley FL. Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation. J Immunol. 2012 Oct 15; 189(8):4060-8. PMID: 22984078.
      Citations: 68     Fields:    Translation:AnimalsCells
    33. Wozniak KL, Hardison S, Olszewski M, Wormley FL. Induction of protective immunity against cryptococcosis. Mycopathologia. 2012 Jun; 173(5-6):387-94. PMID: 22143898.
      Citations: 16     Fields:    Translation:HumansAnimals
    34. Wozniak KL, Young ML, Wormley FL. Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice. Clin Vaccine Immunol. 2011 May; 18(5):717-23. PMID: 21450975.
      Citations: 44     Fields:    Translation:AnimalsCells
    35. Wozniak KL, Hardison SE, Kolls JK, Wormley FL. Role of IL-17A on resolution of pulmonary C. neoformans infection. PLoS One. 2011 Feb 17; 6(2):e17204. PMID: 21359196.
      Citations: 65     Fields:    Translation:AnimalsCells
    36. Hardison SE, Wozniak KL, Kolls JK, Wormley FL. Interleukin-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection. Infect Immun. 2010 Dec; 78(12):5341-51. PMID: 20921149.
      Citations: 44     Fields:    Translation:AnimalsCells
    37. Pereira HA, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen TT, Pohl J, Wozniak K, Fidel PL. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Med Mycol. 2010 Mar; 48(2):263-72. PMID: 19626550.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    38. Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL. Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection. Am J Pathol. 2010 Feb; 176(2):774-85. PMID: 20056835.
      Citations: 82     Fields:    Translation:AnimalsCellsPHPublic Health
    39. Wozniak KL, Ravi S, Macias S, Young ML, Olszewski MA, Steele C, Wormley FL. Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis. PLoS One. 2009 Sep 03; 4(9):e6854. PMID: 19727388.
      Citations: 70     Fields:    Translation:AnimalsCells
    40. Wozniak KL, Levitz SM. Isolation and purification of antigenic components of Cryptococcus. Methods Mol Biol. 2009; 470:71-83. PMID: 19089377.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    41. Wozniak KL, Levitz SM. Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components. Infect Immun. 2008 Oct; 76(10):4764-71. PMID: 18678670.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    42. Wozniak KL, Vyas JM, Levitz SM. In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis. Infect Immun. 2006 Jul; 74(7):3817-24. PMID: 16790753.
      Citations: 51     Fields:    Translation:AnimalsCells
    43. Wozniak KL, Palmer G, Kutner R, Fidel PL. Immunotherapeutic approaches to enhance protective immunity against Candida vaginitis. Med Mycol. 2005 Nov; 43(7):589-601. PMID: 16396244.
      Citations: 8     Fields:    Translation:Animals
    44. Cheng S, Clancy CJ, Checkley MA, Zhang Z, Wozniak KL, Seshan KR, Jia HY, Fidel P, Cole G, Nguyen MH. The role of Candida albicans NOT5 in virulence depends upon diverse host factors in vivo. Infect Immun. 2005 Nov; 73(11):7190-7. PMID: 16239513.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Singleton DR, Fidel PL, Wozniak KL, Hazen KC. Contribution of cell surface hydrophobicity protein 1 (Csh1p) to virulence of hydrophobic Candida albicans serotype A cells. FEMS Microbiol Lett. 2005 Mar 15; 244(2):373-7. PMID: 15766793.
      Citations: 20     Fields:    Translation:Animals
    46. Wozniak KL, Wormley FL, Fidel PL. Candida-specific antibodies during experimental vaginal candidiasis in mice. Infect Immun. 2002 Oct; 70(10):5790-9. PMID: 12228309.
      Citations: 16     Fields:    Translation:HumansAnimals
    47. Wozniak KL, Leigh JE, Hager S, Swoboda RK, Fidel PL. A comprehensive study of Candida-specific antibodies in the saliva of human immunodeficiency virus-positive individuals with oropharyngeal candidiasis. J Infect Dis. 2002 May 01; 185(9):1269-76. PMID: 12001044.
      Citations: 9     Fields:    Translation:HumansAnimals
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