Polymerase Chain Reaction
"Polymerase Chain Reaction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Descriptor ID |
D016133
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MeSH Number(s) |
E05.393.620.500
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Concept/Terms |
Polymerase Chain Reaction- Polymerase Chain Reaction
- Polymerase Chain Reactions
- Reaction, Polymerase Chain
- Reactions, Polymerase Chain
- PCR
Inverse PCR- Inverse PCR
- PCR, Inverse
- Inverse Polymerase Chain Reaction
Anchored PCR- Anchored PCR
- PCR, Anchored
- Anchored Polymerase Chain Reaction
|
Below are MeSH descriptors whose meaning is more general than "Polymerase Chain Reaction".
Below are MeSH descriptors whose meaning is more specific than "Polymerase Chain Reaction".
This graph shows the total number of publications written about "Polymerase Chain Reaction" by people in this website by year, and whether "Polymerase Chain Reaction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 6 | 6 |
1996 | 0 | 8 | 8 |
1997 | 3 | 8 | 11 |
1998 | 0 | 8 | 8 |
1999 | 0 | 6 | 6 |
2000 | 0 | 4 | 4 |
2001 | 1 | 5 | 6 |
2002 | 2 | 9 | 11 |
2003 | 1 | 9 | 10 |
2004 | 1 | 7 | 8 |
2005 | 0 | 11 | 11 |
2006 | 1 | 6 | 7 |
2007 | 0 | 8 | 8 |
2008 | 3 | 8 | 11 |
2009 | 2 | 14 | 16 |
2010 | 2 | 12 | 14 |
2011 | 1 | 9 | 10 |
2012 | 0 | 8 | 8 |
2013 | 2 | 9 | 11 |
2014 | 0 | 11 | 11 |
2015 | 1 | 6 | 7 |
2016 | 0 | 7 | 7 |
2017 | 1 | 3 | 4 |
2018 | 0 | 4 | 4 |
2019 | 1 | 0 | 1 |
2020 | 0 | 3 | 3 |
2021 | 0 | 1 | 1 |
2022 | 0 | 2 | 2 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Polymerase Chain Reaction" by people in Profiles.
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Australasian Pigeon Circoviruses Demonstrate Natural Spillover Infection. Viruses. 2023 09 29; 15(10).
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Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children. Int J Cancer. 2023 03 01; 152(5):845-853.
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Quantitative reverse transcription PCR assay to detect a genetic marker of pyrethroid resistance in Culex mosquitoes. PLoS One. 2022; 17(8):e0252498.
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A novel duplication involving PRDM13 in a Turkish family supports its role in North Carolina macular dystrophy (NCMD/MCDR1). Mol Vis. 2021; 27:518-527.
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First case report of acute cholangitis secondary to Cronobacter sakazakii. BMC Infect Dis. 2021 May 27; 21(1):493.
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Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis. Arthritis Rheumatol. 2020 07; 72(7):1111-1122.
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Toxocara species environmental contamination of public spaces in New York City. PLoS Negl Trop Dis. 2020 05; 14(5):e0008249.
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Human Papillomavirus (HPV69/HPV73) Coinfection associated with Simultaneous Squamous Cell Carcinoma of the Anus and Presumed Lung Metastasis. Viruses. 2020 03 22; 12(3).
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CG/CA genotypes represent novel markers in the NPHS2 gene region associated with nephrotic syndrome. J Genet. 2020; 99.
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Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples. BMC Cancer. 2019 Jan 28; 19(1):106.