"Integrin alphaVbeta3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
| Descriptor ID |
D039302
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| MeSH Number(s) |
D12.776.395.550.625.439 D12.776.543.550.625.439 D12.776.543.750.705.408.460.870.500 D12.776.543.750.705.675.541
|
| Concept/Terms |
Integrin alphaVbeta3- Integrin alphaVbeta3
- alphaVbeta3, Integrin
- alpha-v beta-3 Integrin Receptors
- alpha v beta 3 Integrin Receptors
- Receptors, alpha-v beta-3 Integrin
- Receptors, alpha v beta 3 Integrin
- Vitronectin Receptor
- Receptor, Vitronectin
- Integrin alpha-v beta-3
- Integrin alpha v beta 3
- alpha-v beta-3, Integrin
- beta-3, Integrin alpha-v
|
Below are MeSH descriptors whose meaning is more general than "Integrin alphaVbeta3".
Below are MeSH descriptors whose meaning is more specific than "Integrin alphaVbeta3".
This graph shows the total number of publications written about "Integrin alphaVbeta3" by people in this website by year, and whether "Integrin alphaVbeta3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alphaVbeta3" by people in Profiles.
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Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy. Sci Rep. 2017 11 07; 7(1):14674.
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Synthesis and in vivo evaluation of Tc-99m-labeled cyclic CisoDGRC peptide conjugates for targeting avß3 integrin expression. Bioorg Med Chem Lett. 2010 Oct 15; 20(20):5969-72.
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Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res. 2005 Jan; 20(1):58-66.
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The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function. Thromb Haemost. 2004 Apr; 91(4):743-54.