Interleukin-1 Receptor Accessory Protein
"Interleukin-1 Receptor Accessory Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein that takes part in the formation of active interleukin-1 receptor complex. It binds specifically to INTERLEUKIN-1 and the INTERLEUKIN-1 RECEPTOR TYPE I at the cell surface to form a heterotrimeric complex that brings its cytoplasmic domain into contact with the cytoplasm domain of the TYPE-I INTERLEUKIN-1 RECEPTOR. Activation of intracellular signal transduction pathways from the receptor is believed to be driven by this form of cytoplasmic interaction.
| Descriptor ID |
D053577
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| MeSH Number(s) |
D12.776.543.750.705.852.420.300.249
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1 Receptor Accessory Protein".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1 Receptor Accessory Protein".
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Below are the most recent publications written about "Interleukin-1 Receptor Accessory Protein" by people in Profiles.
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IL1RAPL1 gene deletion as a cause of X-linked intellectual disability and dysmorphic features. Eur J Med Genet. 2012 Jan; 55(1):32-6.