"Presenilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
| Descriptor ID |
D053764
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| MeSH Number(s) |
D12.776.543.696.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Presenilin-1".
Below are MeSH descriptors whose meaning is more specific than "Presenilin-1".
This graph shows the total number of publications written about "Presenilin-1" by people in this website by year, and whether "Presenilin-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Presenilin-1" by people in Profiles.
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DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L441-8.
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Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain Res. 2007 Mar 02; 1135(1):12-21.
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Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer's disease in Mexican families. Neurogenetics. 2006 Jul; 7(3):195-200.