"Tubulin Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.
| Descriptor ID |
D050257
|
| MeSH Number(s) |
D27.505.519.593.249.500
|
| Concept/Terms |
Tubulin Modulators- Tubulin Modulators
- Modulators, Tubulin
- Microtubule Modulators
- Modulators, Microtubule
Tubulin Promoters- Tubulin Promoters
- Promoters, Tubulin
- Tubulin Polymerization Promoters
- Polymerization Promoters, Tubulin
- Promoters, Tubulin Polymerization
Tubulin Inhibitors- Tubulin Inhibitors
- Inhibitors, Tubulin
- Tubulin Polymerization Inhibitors
- Inhibitors, Tubulin Polymerization
- Polymerization Inhibitors, Tubulin
|
Below are MeSH descriptors whose meaning is more general than "Tubulin Modulators".
Below are MeSH descriptors whose meaning is more specific than "Tubulin Modulators".
This graph shows the total number of publications written about "Tubulin Modulators" by people in this website by year, and whether "Tubulin Modulators" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 0 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tubulin Modulators" by people in Profiles.
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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents. Bioorg Med Chem Lett. 2021 06 01; 41:127923.
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Tubulin inhibitory activity of a novel colchicine-binding compounds based on a dinaphthospiropyranran scaffold. Bioorg Med Chem. 2021 01 01; 29:115874.
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Managing acute and recurrent idiopathic pericarditis. JAAPA. 2020 Jan; 33(1):16-22.
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Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers. J Nat Prod. 2019 03 22; 82(3):583-588.
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Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. Mol Cancer Ther. 2017 09; 16(9):1819-1830.
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Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ. J Nat Prod. 2017 02 24; 80(2):409-414.
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Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells. J Nat Prod. 2016 Mar 25; 79(3):531-40.
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Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer. Pancreas. 2015 Aug; 44(6):945-52.
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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. Bioorg Med Chem. 2015 May 15; 23(10):2408-23.
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A Phase II evaluation of ixabepilone (IND #59699, NSC #710428) in the treatment of recurrent or persistent leiomyosarcoma of the uterus: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol Oncol. 2014 Oct; 135(1):44-8.