STAT5 Transcription Factor
"STAT5 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.
| Descriptor ID |
D050799
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| MeSH Number(s) |
D12.644.360.024.342.500 D12.776.157.057.186.500 D12.776.476.024.430.500 D12.776.930.840.500
|
| Concept/Terms |
STAT5 Transcription Factor- STAT5 Transcription Factor
- Factor, STAT5 Transcription
- Transcription Factor, STAT5
- STAT5 Protein
- Signal Transducer and Activator of Transcription 5
STAT5b Transcription Factor- STAT5b Transcription Factor
- Transcription Factor, STAT5b
- STAT5beta Protein
- STAT5b Protein
- Signal Transducer and Activator of Transcription 5B
STAT5a Transcription Factor- STAT5a Transcription Factor
- Transcription Factor, STAT5a
- Mammary Gland Factor
- Signal Transducer and Activator of Transcription 5A
- STAT5alpha Protein
- STAT5a Protein
- Mammary Gland-Specific Nuclear Factor
- Mammary Gland Specific Nuclear Factor
|
Below are MeSH descriptors whose meaning is more general than "STAT5 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "STAT5 Transcription Factor".
This graph shows the total number of publications written about "STAT5 Transcription Factor" by people in this website by year, and whether "STAT5 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "STAT5 Transcription Factor" by people in Profiles.
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The small molecule inhibitor G6 significantly reduces bone marrow fibrosis and the mutant burden in a mouse model of Jak2-mediated myelofibrosis. Am J Pathol. 2012 Sep; 181(3):858-65.
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Role of complement cascade in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1653-60.
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Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010 Apr; 71(4):329-33.
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Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood. 2008 Nov 01; 112(9):3753-61.
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A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood. 2008 Jan 01; 111(1):344-50.
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Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. J Immunol. 2004 Oct 15; 173(8):5036-45.
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Thymocytes between the beta-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J Immunol. 2004 Apr 01; 172(7):4235-44.