Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
| Descriptor ID |
D020875
|
| MeSH Number(s) |
D12.644.400.575.281.075 D12.776.631.650.575.281.075
|
| Concept/Terms |
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- 2-Ala-4-MePhe-5-Gly-Enkephalin
- 2 Ala 4 MePhe 5 Gly Enkephalin
- Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAGO
- DAMGE
- D-Ala2-NMe-Phe4-Gly-ol Enkephalin
- D Ala2 NMe Phe4 Gly ol Enkephalin
- Enkephalin, D-Ala2-NMe-Phe4-Gly-ol
- DAGOL
- Tyr-Ala-Gly-(NMe)Phe-Gly-ol
- Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
- D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAMGO
|
Below are MeSH descriptors whose meaning is more general than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
This graph shows the total number of publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in this website by year, and whether "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Profiles.
-
A pharmacological comparison of the cloned frog and human mu opioid receptors reveals differences in opioid affinity and function. Eur J Pharmacol. 2008 Dec 03; 599(1-3):36-43.
-
Orphanin FQ/nociceptin potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin-Induced mu-opioid receptor phosphorylation. Mol Pharmacol. 2005 Aug; 68(2):447-56.
-
Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther. 2003 Sep; 306(3):965-72.
-
Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure. Neuropharmacology. 2002 Nov; 43(6):979-90.
-
Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9.
-
beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells. Eur J Pharmacol. 2000 Aug 18; 402(1-2):R1-37.
-
Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats. Neurosci Lett. 1995 Sep 29; 198(2):99-102.
-
Gender effects and central opioid analgesia. Pain. 1991 Apr; 45(1):87-94.