Penicillin-Binding Proteins
                             
                            
                            
                                
                            
                            
                                
                            
                            
                            
                                
                                    
                                            
	"Penicillin-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, 
	MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, 
	which enables searching at various levels of specificity.
	
	
		
			
			
				Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.
    
			
			
				
				
					
						| Descriptor ID | D046915 | 
					
						| MeSH Number(s) | D08.811.710 D12.776.097.545 | 
					
						| Concept/Terms | Penicillin-Binding ProteinsPenicillin-Binding ProteinsPenicillin Binding ProteinsProteins, Penicillin-BindingPenicillin-Binding ProteinPenicillin Binding Protein
 | 
					
				
			 
			
				Below are MeSH descriptors whose meaning is more general than "Penicillin-Binding Proteins".
				
			 
			
			
				Below are MeSH descriptors whose meaning is more specific than "Penicillin-Binding Proteins".
				
			 
		 
	 
 
                                        
                                            
	
	
		
			
			
					
				This graph shows the total number of publications written about "Penicillin-Binding Proteins" by people in this website by year, and whether "Penicillin-Binding Proteins" was a major or minor topic of these publications. 
				
					 
                    To see the data from this visualization as text, 
click here. 
                
		            | Year | Major Topic | Minor Topic | Total | 
|---|
| 2011 | 1 | 0 | 1 | 
| 2016 | 0 | 1 | 1 | 
| 2018 | 0 | 1 | 1 | 
| 2019 | 1 | 0 | 1 | 
| 2023 | 0 | 1 | 1 | 
                    To return to the timeline, 
click here.
                 
			 	
			
			
			
			
				Below are the most recent publications written about "Penicillin-Binding Proteins" by people in Profiles.
						
					
								- 
								Penicillin-binding protein redundancy in Bacillus subtilis enables growth during alkaline shock. Appl Environ Microbiol. 2024 01 24; 90(1):e0054823. 
- 
								BPEI-Induced Delocalization of PBP4 Potentiates ß-Lactams against MRSA. Biochemistry. 2019 09 10; 58(36):3813-3822. 
- 
								Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin-Resistant Staphylococcus epidermidis (MRSE). ChemMedChem. 2018 10 22; 13(20):2240-2248. 
- 
								Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine). J Antibiot (Tokyo). 2016 Dec; 69(12):871-878. 
- 
								Compensatory evolution of pbp mutations restores the fitness cost imposed by ß-lactam resistance in Streptococcus pneumoniae. PLoS Pathog. 2011 Feb; 7(2):e1002000.