"Smad3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
| Descriptor ID |
D051900
|
| MeSH Number(s) |
D12.644.360.024.334.500.300 D12.776.157.057.170.500.300 D12.776.260.713.500.300 D12.776.476.024.428.500.300 D12.776.744.741.875 D12.776.930.806.500.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad3 Protein".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- Adaptor Proteins, Signal Transducing [D12.644.360.024]
- Smad Proteins [D12.644.360.024.334]
- Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
- Smad3 Protein [D12.644.360.024.334.500.300]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Adaptor Proteins, Signal Transducing [D12.776.157.057]
- Smad Proteins [D12.776.157.057.170]
- Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
- Smad3 Protein [D12.776.157.057.170.500.300]
- DNA-Binding Proteins [D12.776.260]
- Smad Proteins [D12.776.260.713]
- Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
- Smad3 Protein [D12.776.260.713.500.300]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- Adaptor Proteins, Signal Transducing [D12.776.476.024]
- Smad Proteins [D12.776.476.024.428]
- Smad Proteins, Receptor-Regulated [D12.776.476.024.428.500]
- Smad3 Protein [D12.776.476.024.428.500.300]
- Phosphoproteins [D12.776.744]
- Smad Proteins, Receptor-Regulated [D12.776.744.741]
- Smad3 Protein [D12.776.744.741.875]
- Transcription Factors [D12.776.930]
- Smad Proteins [D12.776.930.806]
- Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
- Smad3 Protein [D12.776.930.806.500.300]
Below are MeSH descriptors whose meaning is more specific than "Smad3 Protein".
This graph shows the total number of publications written about "Smad3 Protein" by people in this website by year, and whether "Smad3 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Smad3 Protein" by people in Profiles.
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A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-ß/Smad signaling. Signal Transduct Target Ther. 2020 04 29; 5(1):45.
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Long Noncoding RNA FENDRR Exhibits Antifibrotic Activity in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2020 04; 62(4):440-453.
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Efficacy of ALK5 inhibition in myelofibrosis. JCI Insight. 2017 04 06; 2(7):e90932.
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Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. J Nutr. 2014 Mar; 144(3):258-66.
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Acute loading and aging effects on myostatin pathway biomarkers in human skeletal muscle after three sequential bouts of resistance exercise. J Gerontol A Biol Sci Med Sci. 2011 Aug; 66(8):855-65.
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Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Mol Carcinog. 2011 Jan; 50(1):8-15.
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Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. Am J Pathol. 2009 Jan; 174(1):317-29.
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Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun. 2008 Feb 08; 366(2):563-7.
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Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Diabetes. 2006 Jun; 55(6):1678-85.
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Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol. 2005 Feb; 96(2):368-73.