Valosin Containing Protein
"Valosin Containing Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
| Descriptor ID |
D000074405
|
| MeSH Number(s) |
D08.811.277.040.013.500.750 D08.811.277.040.025.024.750 D12.776.157.025.750.750 D12.776.167.800
|
| Concept/Terms |
Valosin Containing Protein- Valosin Containing Protein
- Cell Cycle Protein CDC48
- Valosine-Containing Protein
- Valosine Containing Protein
- p97 Valosin-Containing Protein
- Valosin-Containing Protein, p97
- p97 Valosin Containing Protein
- Valosin-Containing Protein
- CDC48 Protein
- Cell Cycle Protein CDC48p
|
Below are MeSH descriptors whose meaning is more general than "Valosin Containing Protein".
Below are MeSH descriptors whose meaning is more specific than "Valosin Containing Protein".
This graph shows the total number of publications written about "Valosin Containing Protein" by people in this website by year, and whether "Valosin Containing Protein" was a major or minor topic of these publications.
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Below are the most recent publications written about "Valosin Containing Protein" by people in Profiles.
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Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression. PLoS One. 2016; 11(7):e0158507.
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Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma. PLoS One. 2011; 6(12):e29073.
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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema. J Mol Med (Berl). 2011 Jun; 89(6):577-93.
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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec 14; 187(6):875-88.
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TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2008 Oct; 79(10):1186-9.
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Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease. J Biol Chem. 2008 Oct 31; 283(44):30289-99.
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Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice. Hum Mol Genet. 2007 Apr 15; 16(8):919-28.