"Cholera Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
| Descriptor ID |
D002772
|
| MeSH Number(s) |
D08.811.913.400.725.115.180 D23.946.123.194 D23.946.330.150
|
| Concept/Terms |
Cholera Toxin- Cholera Toxin
- Toxin, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Choleragen
- Cholera Enterotoxin CT
- CT, Cholera Enterotoxin
- Enterotoxin CT, Cholera
Choleragenoid- Choleragenoid
- Cholera Toxin Protomer B
- Cholera Toxin B Subunit
|
Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".
Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".
This graph shows the total number of publications written about "Cholera Toxin" by people in this website by year, and whether "Cholera Toxin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cholera Toxin" by people in Profiles.
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Immunogenicity of a Staphylococcus aureus-cholera toxin A2/B vaccine for bovine mastitis. Vaccine. 2018 06 07; 36(24):3513-3521.
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IL-22 deficiency increases CD4 T cell responses to mucosal immunization. Vaccine. 2018 06 14; 36(25):3694-3700.
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N-glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential. Sci Rep. 2015 Jan 23; 5:8003.
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Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons (Papio sp.). Vaccine. 2012 Apr 26; 30(20):3068-75.
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Adherence-inhibitory intestinal immunoglobulin a antibody response in baboons elicited by use of a synthetic intranasal lectin-based amebiasis subunit vaccine. Infect Immun. 2007 Aug; 75(8):3812-22.
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[Lateral orbital decompression for Graves' orbitopathy. Indication, surgical technique, and treatment success]. Ophthalmologe. 2004 Apr; 101(4):339-49.
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Extracellular matrix proteins are potent agonists of human smooth muscle cell migration. J Vasc Surg. 1996 Jul; 24(1):25-32; discussion 32-3.
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Mechanisms of proton-induced stimulation of CGRP release from rat antrum. Regul Pept. 1995 Sep 22; 59(1):103-9.